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Five different models were constructed from this molar in group 1 as follows: intact molar model, root filled (<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>) model and three models with furcal perforations (1, 2 and 3\u00a0mm in diameter) repaired with a calcium silicate\u2010based cement (<jats:styled-content style=\"fixed-case\">CSC<\/jats:styled-content>). In group 2, a lesion simulating bone resorption at the furcal region was modelled on the models in group 1. A force of 200\u00a0N was applied to simulate normal occlusal loads. Static linear <jats:styled-content style=\"fixed-case\">FEA<\/jats:styled-content> was performed using the Abaqus software (Abaqus 6.14; <jats:styled-content style=\"fixed-case\">ABAQUS<\/jats:styled-content> Inc., Providence, <jats:styled-content style=\"fixed-case\">RI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> USA<\/jats:styled-content>). The maximum principal stresses (<jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub>) and maximum displacement magnitude were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The range of <jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub> values of the models in group 1, from high to low, was as follows: <jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a03\u00a0mm perforation\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a02\u00a0mm perforation\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a01\u00a0mm perforation\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0&gt;\u00a0intact model, and the range of <jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub> values of the models in group 2 was as follows: <jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a03\u00a0mm perforation\u00a0+\u00a0furcal lesion\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a02\u00a0mm perforation\u00a0+\u00a0furcal lesion\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a01\u00a0mm perforation\u00a0+\u00a0furcal lesion\u00a0&gt;\u00a0<jats:styled-content style=\"fixed-case\">RCF<\/jats:styled-content>\u00a0+\u00a0furcal lesion\u00a0&gt;\u00a0intact model\u00a0+\u00a0furcal lesion. All of the models in group 2 exhibited lower <jats:italic>P<\/jats:italic><jats:sub>max<\/jats:sub> values and higher maximum displacement magnitude than their counterparts without lesions in group 1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The size of the furcal perforation affected the accumulation and distribution of stress within the models. Mandibular molar teeth with large furcal perforations treated with a calcium silicate\u2010based cement may be associated with an increased risk of fracture whether or not accompanied by bone resorption.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13013","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T17:27:26Z","timestamp":1536341246000},"page":"377-384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Effect of perforation size and furcal lesion on stress distribution in mandibular molars: a finite element analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-6086","authenticated-orcid":false,"given":"S.","family":"Askerbeyli \u00d6rs","sequence":"first","affiliation":[{"name":"Department of Endodontology Faculty of Dentistry Hacettepe University S\u0131hhiye Ankara 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