{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:24:09Z","timestamp":1783434249824,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T00:00:00Z","timestamp":1541721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the prevalence, pain catastrophizing and other predictive factors and clinical course of persistent pain\/discomfort associated with teeth displaying periapical healing following nonsurgical root canal treatment (<jats:styled-content style=\"fixed-case\">NSRCT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>One hundred and ninety\u2010eight patients (264 teeth) who had <jats:styled-content style=\"fixed-case\">NSRCT<\/jats:styled-content> were reviewed at 5\u201314\u00a0months, postoperatively. Teeth with persistent post\u2010treatment pain or discomfort, plus evidence of periapical healing were further monitored 0.5, 4 and 10\u00a0years later. Pain Catastrophizing Scale (<jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>) and Short Form of the McGill Pain Questionnaire (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MPQ<\/jats:styled-content>) were completed. Predictive factors were investigated using logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four per cent (60\/249) of teeth displaying periapical healing at first review were associated with persistent pain or discomfort. Fifty\u2010five teeth monitored 6\u20137\u00a0months later were associated with reduction in pain (17\/30) or discomfort (7\/25). Cone beam computed tomography (CBCT) of eight teeth with persistent symptoms and complete periapical healing (by conventional radiographs) revealed distinct, small apical radiolucencies (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) or root apex fenestration through the buccal plate (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). History of chronic pain (headache, temporo\u2010mandibular joint, masticatory muscle, neck, shoulder or back pain; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005), preoperative pain (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04), responsive pulp (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.009), tooth crack (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.05) and small periapical radiolucency (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005) were significant predictive factors. The <jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content> revealed 16 patients (22 teeth) were catastrophizers (<jats:styled-content style=\"fixed-case\">PCS<\/jats:styled-content>\u00a0\u2265\u00a030), but this had no influence on post\u2010treatment symptoms (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent pain or discomfort associated with teeth showing periapical healing at the first review after <jats:styled-content style=\"fixed-case\">NSRCT<\/jats:styled-content>, decreased in intensity in most cases over the following 6\u00a0months. Longer\u2010term follow\u2010up revealed spontaneous improvement or symptom resolution in the majority of those with confirmed radiographic the absence of periapical disease. Five predictive factors (history of chronic pain, teeth with responsive pulps, association with pain, diagnosis of tooth crack before treatment and diameter of preoperative radiolucency) were identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13029","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T21:43:16Z","timestamp":1539812596000},"page":"407-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence, predictive factors and clinical course of persistent pain associated with teeth displaying periapical healing following nonsurgical root canal treatment: a prospective study"],"prefix":"10.1111","volume":"52","author":[{"given":"R.","family":"Philpott","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry Edinburgh Dental Institute University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gulabivala","sequence":"additional","affiliation":[{"name":"Unit of Endodontology UCL Eastman Dental Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Leeson","sequence":"additional","affiliation":[{"name":"Unit of Maxillo\u2010Facial Surgery UCL Eastman Dental Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-8836","authenticated-orcid":false,"given":"Y.\u2010L.","family":"Ng","sequence":"additional","affiliation":[{"name":"Unit of Endodontology UCL Eastman Dental Institute University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2006.02.033"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90564-S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0283"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2012.11.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.07.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2012.00144.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2005.11.038"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12651"},{"key":"e_1_2_8_10_1","first-page":"259","article-title":"The prevalence of persistent pain after nonsurgical root canal treatment","volume":"42","author":"Klasser GD","year":"2011","journal-title":"Quintessence International"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(95)80024-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/970423"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(78)80211-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1996.0172"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90285-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.115135"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2007.01323.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01872.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2011.02247.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.12.012"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000343"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00236-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200010000-00038"},{"key":"e_1_2_8_25_1","volume-title":"Statistics for veterinary and animal science","author":"Petrie A","year":"1999"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01923.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1033"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2004.00923.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.11.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.5116\/ijme.4dfb.8dfd"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.07.026"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1998.tb00200.x"},{"key":"e_1_2_8_33_1","first-page":"226","article-title":"Patients\u2019 experiences of consultations for nonspecific chronic orofacial pain: a phenomenological study","volume":"20","author":"Wolf E","year":"2006","journal-title":"Journal of Orofacial Pain"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.13029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:39:37Z","timestamp":1694396377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.13029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,9]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/iej.13029"],"URL":"https:\/\/doi.org\/10.1111\/iej.13029","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,9]]},"assertion":[{"value":"2018-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}