{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:58:17Z","timestamp":1775523497538,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the prevalence of cholesterol crystals in periapical biopsies and to evaluate the correlation between cholesterol crystals in periapical biopsies and age, gender, location of the periapical lesion, pathologic diagnosis and lesion size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>The biopsy report database (Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand) during 2005\u20132014 was reviewed. The prevalence of cholesterol crystals in the periapical lesions of root filled teeth was determined. Pathological diagnosis, patients\u2019 age, gender and the location (maxilla or mandible) of the periapical lesion were obtained from treatment records. The area of the lesion from the periapical radiograph before surgery was calculated using ImageJ software. Univariate and multivariate logistic regression analyses were used to determine the association between independent variables and the presence of cholesterol crystals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of cholesterol crystals was 20.31%. The periapical biopsies &gt;100\u00a0mm<jats:sup>2<\/jats:sup> in size on periapical films had a significantly greater prevalence of cholesterol crystals than those &lt;100\u00a0mm<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). The biopsies diagnosed as radicular cysts had a significantly greater prevalence of cholesterol crystals than the biopsies with other diagnoses (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). A pathological diagnosis of radicular cyst was the variable with the strongest association with the presence of cholesterol crystals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 12.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Presence of cholesterol crystals was associated with periapical lesion diagnosed as a radicular cyst and lesion &gt;100\u00a0mm<jats:sup>2<\/jats:sup> in area. Age, gender and location of the lesion did not influence the presence of cholesterol crystals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13030","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T05:14:45Z","timestamp":1540012485000},"page":"484-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cholesterol crystals in periapical lesions of root filled teeth"],"prefix":"10.1111","volume":"52","author":[{"given":"C.","family":"Plengwitthaya","sequence":"first","affiliation":[{"name":"Section\u00a0of Endodontics Department of Operative Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Dhanuthai","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chantarangsu","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-1540","authenticated-orcid":false,"given":"C.","family":"Ratisoontorn","sequence":"additional","affiliation":[{"name":"Section\u00a0of Endodontics Department of Operative Dentistry Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01186-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(71)90141-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4526(06)51003-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12506"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.09.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0313-z"},{"key":"e_1_2_7_10_1","volume-title":"Root Canal Therapy","author":"Grossman LI","year":"1950"},{"key":"e_1_2_7_11_1","volume-title":"Biochemistry","author":"Harvey RA","year":"2005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(65)90166-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511000237"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80201-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80202-0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1993.tb00563.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1998.eos106206.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90267-6"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.12.030"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.11.005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70266-8"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2013.03.001"},{"key":"e_1_2_7_24_1","first-page":"354","article-title":"Incidence of radicular cysts in a series of 125 chronic periapical lesions. 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