{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:52:28Z","timestamp":1789757548572,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund for Postgraduate Students of the Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the outcome of partial pulpotomy using two cements, ProRoot MTA (Dentsply, Tulsa Dental Specialties, Tulsa, OK, USA) and Biodentine (Septodont, Saint\u2010Maur\u2010des\u2010Foss\u00e9s, France), in permanent teeth of 6\u2010 to 18\u2010year\u2010old patients with signs and symptoms indicative of irreversible pulpitis. Furthermore, the frequencies of perceptible grey discoloration caused by the cements were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010nine permanent first molars with signs and symptoms indicative of irreversible pulpitis, from 69 patients, were included. All operators performed partial pulpotomy under a standardized protocol. Teeth were allocated, using a website\u2010generated number of simple randomization, to partial pulpotomy with either ProRoot MTA (37 teeth) or Biodentine (32 teeth) and were restored with composite resin or stainless steel crowns. Patients were recalled every 6\u00a0months. To be categorized as having success, the evaluated tooth must have had both clinical and radiographic success. In addition, photographs of treated teeth were evaluated for frequency of perceptible grey discoloration. Success rates between the two cements were compared using the Fisher exact test. The frequencies of perceptible grey discoloration were compared using the chi\u2010square test. The percentage difference was estimated by 95% confidence interval, and the level of significant difference was\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At a mean follow\u2010up of 32.2\u00a0\u00b1\u00a017.9 months, a total of 67 teeth, 37 with ProRoot MTA and 30 with Biodentine, were available for evaluation. The mean age of participants was 10\u00a0\u00b1\u00a02.1\u00a0years and, there were no differences in the baseline variables (gender, age, tooth type, periapical status, stage of root development, final restoration and follow\u2010up period) between the groups. The overall success in both groups was 90%, with 92% for ProRoot MTA and 87% for Biodentine (difference, 5%; 95% confidence interval, \u22129% to 19%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.487), suggesting that Biodentine was noninferior to ProRoot MTA. Perceptible grey discoloration was observed in both groups, 80% for teeth treated with ProRoot MTA and 27% for teeth treated with Biodentine, with a significant difference between the materials (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Permanent teeth with signs and symptoms indicative of irreversible pulpitis in 6\u2010 to 18\u2010year\u2010old patients were successfully treated with partial pulpotomy using both cements. Biodentine exhibited significantly less frequency of discoloration than did ProRoot MTA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13071","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T05:18:56Z","timestamp":1547443136000},"page":"749-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Partial pulpotomy with two bioactive cements in permanent teeth of 6\u2010 to 18\u2010year\u2010old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial"],"prefix":"10.1111","volume":"52","author":[{"given":"N.","family":"Uesrichai","sequence":"first","affiliation":[{"name":"Faculty of Dentistry Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nirunsittirat","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Chiang Mai 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