{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:16:11Z","timestamp":1788480971220,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The management of pain during root canal treatment is important. The aim of this systematic review and network meta\u2010analysis was to identify the anaesthetic solution that would provide the best pulpal anaesthesia for inferior alveolar nerve blocks (<jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content>) treating mandibular teeth with irreversible pulpitis. Two electronic databases (PubMed and Scopus) were searched to identify studies up to October 2018. Randomized clinical trials comparing at least two anaesthetic solutions (lidocaine (lignocaine), articaine, bupivacaine, prilocaine or mepivacaine) used for <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> for treatment of irreversible pulpitis were included. The revised Cochrane risk of bias tool for randomized trials was used to assess the quality of the included studies. Pairwise meta\u2010analysis, network meta\u2010analysis using a random\u2010effects model, and <jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content> ranking were performed. The network meta\u2010analysis estimated the probability of each treatment performing best. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations approach. In total, 11 studies (<jats:italic>n<\/jats:italic>\u00a0=\u00a0750) were included in the meta\u2010analysis. The network meta\u2010analysis revealed that only mepivacaine significantly increased the success rate of <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> compared to lidocaine (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>, 1.42 [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.04\u20131.95]). However, no significant differences in the success rate of <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> were observed between mepivacaine and other anaesthetic agents (articaine and bupivacaine). Of all anaesthetic agents, mepivacaine (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>\u00a0=\u00a00.81) ranked first in increasing the success rate of <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content>, followed by prilocaine (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>\u00a0=\u00a00.62), articaine (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>\u00a0=\u00a00.54), bupivacaine (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>\u00a0=\u00a00.41) and lidocaine (<jats:styled-content style=\"fixed-case\">SUCRA<\/jats:styled-content>\u00a0=\u00a00.13). The overall quality of evidence was very low to moderate. In conclusion, based on the evidence from the randomized clinical trials included in this review, mepivacaine with epinephrine demonstrated the highest probability of providing effective pulpal anaesthesia using <jats:styled-content style=\"fixed-case\">IANB<\/jats:styled-content> for teeth with irreversible pulpitis compared to prilocaine, articaine, bupivacaine and lidocaine. Further, high\u2010quality clinical trials are needed to support the conclusion of this review.<\/jats:p>","DOI":"10.1111\/iej.13072","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T10:16:01Z","timestamp":1547460961000},"page":"779-789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy of local anaesthetic solutions on the success of inferior alveolar nerve block in patients with irreversible pulpitis: a systematic review and network meta\u2010analysis of randomized clinical trials"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-3156","authenticated-orcid":false,"given":"V.","family":"Nagendrababu","sequence":"first","affiliation":[{"name":"Division of Clinical Dentistry School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-8255","authenticated-orcid":false,"given":"S. J.","family":"Pulikkotil","sequence":"additional","affiliation":[{"name":"Division of Clinical Dentistry School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Penang International Dental College Butterworth Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Veettil","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice School of Pharmacy International Medical University Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Division of Clinical Dentistry School of Dentistry International Medical University Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-1398","authenticated-orcid":false,"given":"F. C.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Department of Endodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12249"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.04.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2344\/15-00019.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1642"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1190"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201600663"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.10.012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2011.0219"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(97)00049-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DON.0000125317.21892.8F"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)81366-X"},{"key":"e_1_2_7_13_1","first-page":"22","article-title":"Comparison of the success rates of four anesthetic solutions for inferior alveolar nerve block in patients with irreversible pulpitis. A prospective, randomized, double\u2010blind study","volume":"1","author":"Cunha RS","year":"2011","journal-title":"Dental Press Endodontics"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.12.025"},{"key":"e_1_2_7_15_1","first-page":"579","article-title":"Retrospective review of voluntary reports of nonsurgical paresthesia in dentistry","volume":"75","author":"Gaffen AS","year":"2009","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_7_16_1","first-page":"546","article-title":"An update on local anesthetics in dentistry","volume":"68","author":"Haas DA","year":"2002","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_7_17_1","first-page":"319","article-title":"A 21\u00a0year retrospective study of reports of paresthesia following local anesthetic administration","volume":"61","author":"Haas DA","year":"1995","journal-title":"Journal of the Canadian Dental Association"},{"key":"e_1_2_7_18_1","first-page":"29","volume-title":"Cochrane Database of Systematic Reviews","author":"Higgins JPT","year":"2016"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200310000-00004"},{"key":"e_1_2_7_21_1","first-page":"803","article-title":"Indirect comparisons and network meta\u2010analyses","volume":"112","author":"Kiefer C","year":"2015","journal-title":"Deutsches Arzteblatt International"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(86)80204-7"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.07.001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-016-0715-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.07.013"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12293"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.02.017"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199818040-00001"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(98)80053-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200311000-00010"},{"key":"e_1_2_7_31_1","first-page":"1","article-title":"Various strategies for pain\u2010free root canal treatment","volume":"9","author":"Parirokh MV","year":"2014","journal-title":"Iranian Endodontic Journal"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2015.40.2.155"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.09.009"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5630"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12912"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90372-3"},{"key":"e_1_2_7_37_1","first-page":"333","article-title":"Network meta\u2010analysis to synthesize evidence for decision making in cardiovascular research","volume":"106","author":"Roever L","year":"2016","journal-title":"Arquivos Brasileiros Cardiologia"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.01.008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2009.01562.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51617"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12087"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12125"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.18549\/PharmPract.2017.01.943"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.10.020"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys222"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12926"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.06.015"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(07)80138-5"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiej.13072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.13072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T23:05:29Z","timestamp":1694387129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.13072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/iej.13072"],"URL":"https:\/\/doi.org\/10.1111\/iej.13072","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,12]]},"assertion":[{"value":"2018-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}