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Fifteen animals were divided into three groups with five rats in each group: control group, Ef<\/jats:italic>\u2010CAP<\/jats:styled-content> group and Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group. The maxilla and mandible were harvested and then scanned by micro\u2010CT<\/jats:styled-content>. Alveolar bone destruction was evaluated by measuring the volume of alveolar bone resorption, bone volume fraction (BV<\/jats:styled-content>\/TV<\/jats:styled-content>), trabecular thickness (Tb. Th), trabecular number (Tb. N) and trabecular spacing (Tb. Sp). The results were analysed using one\u2010way analysis of variance and Fisher's least significant difference methods (LSD<\/jats:styled-content>). The sclerotic changes in the periapical bone were graded and the IRR<\/jats:styled-content> indexes were scored. The data were analysed using the chi\u2010square test.<\/jats:p><\/jats:sec>Results<\/jats:title>The alveolar bone resorption volume of the Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group was significantly larger than that of the Ef<\/jats:italic>\u2010CAP<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01). In the maxilla, both Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> and Ef<\/jats:italic>\u2010CAP<\/jats:styled-content> groups had a significant decrease in BV<\/jats:styled-content>\/TV<\/jats:styled-content> and increase in Tb. Sp (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.01) with the more significant changes of trabecular bone in the Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group. A significant reduction of Tb. N was only found in the Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). There was no significant change in Tb. Th in either group (P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.05). In the mandible, except for an increase in Tb. Sp in the Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), there was no significant change in BV<\/jats:styled-content>\/TV<\/jats:styled-content>, Tb. Th or Tb. N (P\u00a0<\/jats:italic>>\u00a0<\/jats:italic>0.05). No obvious sclerotic change was observed. IRR<\/jats:styled-content> was detected in significantly more root surfaces in the Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> group (240 surfaces, 60%) than those in the Ef<\/jats:italic>\u2010CAP<\/jats:styled-content> group (178 surfaces, 44.5%) (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). The IRR<\/jats:styled-content> extension was also significantly more advanced in the Pg\u2010<\/jats:italic>CAP<\/jats:styled-content> group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Pg<\/jats:italic>\u2010CAP<\/jats:styled-content> caused more substantial alveolar bone destruction and IRR<\/jats:styled-content> than Ef<\/jats:italic>\u2010CAP<\/jats:styled-content>. The maxilla was more susceptible to CAP<\/jats:styled-content> in terms of microstructural changes of trabecular bone than the mandible. Tb. Sp was the most sensitive index for evaluating the residual alveolar bone of CAP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13095","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T11:30:49Z","timestamp":1549625449000},"page":"1028-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Micro\u2010CT<\/scp> analysis of chronic apical periodontitis induced by several specific pathogens"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-2485","authenticated-orcid":false,"given":"S.","family":"Chen","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University Fuzhou China"},{"name":"Key Laboratory of Stomatology Fujian Province University Fuzhou 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