{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:43Z","timestamp":1789016323046,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To investigate the possible therapeutic effects of alpha\u2010lipoic acid (ALA<\/jats:styled-content>) in a model of chronic apical periodontitis in rats by analysing biochemical, histopathological and micro\u2010CT<\/jats:styled-content> parameters.<\/jats:p><\/jats:sec>Methodology<\/jats:title>The study was approved by the Animal Ethics Committee of the Near East University. Thirty\u2010two Wistar rats were divided into four groups of eight rats each: Control Group; ALA<\/jats:styled-content> Group; AP<\/jats:styled-content> Group; AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> Group. In the AP<\/jats:styled-content> and AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> groups, the pulp chambers of the mandibular first molars were surgically exposed and were left open to the oral environment for 4\u2010weeks to allow the establishment of periapical lesions. The rats in the Control and AP<\/jats:styled-content> groups were treated intraperitoneally with saline solution (with a daily dose of 100\u00a0mg\u00a0kg\u22121<\/jats:sup>, for 28\u00a0days after periapical lesion induction). The rats in the ALA<\/jats:styled-content> and AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> groups were treated intraperitoneally with ALA<\/jats:styled-content> (with a daily dose of 100\u00a0mg\u00a0kg\u22121<\/jats:sup>, for 28\u00a0days after periapical lesion induction). After decapitation, the trunk blood was collected for the assessment of biochemical parameters. The mandibles were surgically removed and dissected for histopathologic analysis and further scanned with micro\u2010CT<\/jats:styled-content>. Groups of data were compared with a two\u2010way analysis of variance (two\u2010way anova<\/jats:sc>) followed by Sidak's multiple comparison tests. Values of P<\/jats:italic>\u00a0<\u00a00.05 were regarded as significant.<\/jats:p><\/jats:sec>Results<\/jats:title>TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u20101\u03b2, MMP<\/jats:styled-content>\u20101, MMP<\/jats:styled-content>\u20102 levels were significantly lower in AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> group compared with AP<\/jats:styled-content> group (P<\/jats:italic>\u00a0<\u00a00.05). There was a significant difference between the AP<\/jats:styled-content> and AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> groups according to assessment of the inflammatory scores (P<\/jats:italic>\u00a0<\u00a00.05). The periapical inflammatory infiltrates were significantly more severe (P<\/jats:italic>\u00a0<\u00a00.05) in the AP<\/jats:styled-content> group. The AP<\/jats:styled-content>\u00a0+\u00a0ALA<\/jats:styled-content> group exhibited lower values both in terms of surface area and volume of resorption cavities than the AP<\/jats:styled-content> group and this difference was significant (P<\/jats:italic>\u00a0<\u00a00.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>alpha\u2010lipoic acid treatment provided therapeutic effects on the inhibition of periapical bone loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13121","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T11:54:01Z","timestamp":1553255641000},"page":"1317-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of alpha\u2010lipoic acid therapy on experimentally induced apical periodontitis: a biochemical, histopathological and micro\u2010CT 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