{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:50Z","timestamp":1787014310190,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To establish the effects of submucosal single doses of two medicines on postoperative pain after root canal treatment in mandibular molar teeth with symptomatic irreversible pulpitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In this randomized controlled, double\u2010blind clinical trial, 90 patients with the diagnosis of symptomatic irreversible pulpitis in their mandibular first or second molars were included and randomly divided into three groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030): a control group that received normal saline and two experimental groups that received a single dose of either tramadol (100\u00a0mg\u00a02\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) or dexamethasone (8\u00a0mg\u00a02\u00a0mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      ). After local anaesthesia and before treatment, submucosal injections were administered into the mucobuccal fold adjacent to the mandibular molars, and a routine single\u2010visit root canal treatment procedure was performed in all groups. After the root canal treatments, the patients were asked to score their pain level using the Heft\u2013Parker visual analogue scale (0\u2013170\u00a0mm) at 6, 12, 24, 48 and 72\u00a0h. The experimental groups were compared using one\u2010way\n                      <jats:sc>anova<\/jats:sc>\n                      or Kruskal\u2013Wallis H\u2010test. The groups that were significantly different were compared pairwise using Student's t\u2010test or the Mann\u2013Whitney U\u2010test. The findings were expressed as the mean\u00a0\u00b1\u00a0standard deviation or median (min\u2010max). The categorical variables were tested using the chi\u2010square test or Fisher's exact chi\u2010square test, and the results were expressed as counts and percentages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 6\u2010h and 48\u2010h time intervals, the intensity of pain was significantly less in both the dexamethasone and tramadol groups than in the control group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0167). At the end of 12\u00a0h, the pain level in the dexamethasone group was significantly less compared to the other groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0167).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pretreatment submucosal dexamethasone and tramadol injections significantly diminished post\u2010treatment endodontic pain of patients with symptomatic irreversible pulpitis following single\u2010visit root canal treatment. 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