{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:25Z","timestamp":1792801465667,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:00:00Z","timestamp":1576540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/11419\u20100"],"award-info":[{"award-number":["2016\/11419\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To quantify M1 and M2 macrophages in radicular cysts of permanent (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014 cases) and primary teeth (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015 cases).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>All patients who attended the School of Dentistry Ribeir\u00e3o Preto, University of S\u00e3o Paulo with primary teeth or permanent molars that were scheduled for extraction and fulfilled the inclusion criteria: absence of pain; presence\/absence of fistulae; extensive coronal destruction due to caries lesions without possibility of restoration; pulp necrosis; radiographically visible apical periodontitis; and no previous treatment, were selected. The radicular cysts were removed and subsequently submitted to histopathologic analysis in order to classify the type of inflammatory infiltrate. In addition, CD68 (M1+, M2+) and CD163 (M1\u2212, M2+) markers were quantified through an immunohistochemistry analysis. The data acquired were submitted to a Mann\u2013Whitney test, with a 5% significance level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients had a mean age of 38.6\u00a0years and 5.9\u00a0years for cysts associated with permanent and primary teeth, respectively. In the histopathological analysis, no significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.87) was found between radicular cysts in primary and permanent teeth regarding the intensity of the chronic inflammatory infiltrate. A significantly greater prevalence of M2 macrophages (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) was observed in the lesions of both permanent and primary teeth, even though both M1 and M2 macrophages were detected. No significant difference (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &gt;\u00a00.05) was found for M1 and M2 macrophages associated with the cysts of primary and permanent teeth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>M1 and M2 macrophages were present in radicular cysts associated with primary and permanent teeth, with a greater quantity of M2 cells. The immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts associated with primary and permanent teeth were similar.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13257","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T04:53:17Z","timestamp":1576558397000},"page":"627-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immunophenotypic quantification of M1 and M2 macrophage polarization in radicular cysts of\u00a0primary and permanent teeth"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-5302","authenticated-orcid":false,"given":"A. S.","family":"Bertasso","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"L\u00e9on","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Public Oral Health and Forensic Dentistry School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A. B.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A. 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