{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:24:49Z","timestamp":1790083489743,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This 60\u2010month prospective study aimed to evaluate tooth survival and healing rates after root canal treatment in patients taking bisphosphonates (BPs). Secondary outcomes were complications and clinical variables observed during and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Root canal treatment was performed using manual K\u2010file canal instrumentation and a carrier\u2010based filling technique with an epoxy resin\u2010based sealer. Teeth without adequate root\/crown integrity were restored by trained operators at the tissue level (TL group) to prevent occlusal\/mechanical stress and to enable periapical lesion healing without the risk of root fracture. Other teeth were restored with normal occlusal contacts (OC group). Healthy patients who had undergone one or more root canal treatments of the same type constituted the control group. The relationships of the following variables to survival and health status were examined (chi\u2010squared test and multivariate analysis, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05): age, gender, smoking habit, tooth location, treatment type, BPs treatment, BPs exposure, initial periapical index (PAI) and occlusal restoration. Survival curves were constructed using Kaplan\u2013Meier analysis, with extraction serving as the end\u2010point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 65 patients with 109 root canal\u2010treated teeth who were taking BPs were included. At 60\u00a0months, data from 57 patients (52F, 5M; median age 65.7\u00a0\u00b1\u00a08.6\u00a0years) who had undergone 96 root canal treatments were analysed (drop\u2010out rate\u00a0=\u00a016.9%). The survival rate was 85%, and the success rate was 76%. The control group consisted of 46 patients (21F, 25M; median age 60.3\u00a0\u00b1\u00a07.2\u00a0years) who had undergone 102 root canal treatments. The survival rate was 88%, with 12 teeth lost during follow\u2010up. The success rate was 73%. In the BP group, 55 teeth were restored normally (OC group) and 41 teeth were restored at the tissue level (TL group). No difference in the success or survival rate was observed between the BP and control groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Univariate Kaplan\u2013Meier analysis revealed that only tooth type significantly affected survival status in the BP group. The analysis revealed the clinical relevance of smoking, tooth location and initial PAI on patients\u2019 health status (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Root canal treatments and post\u2010endodontic restoration with tissue\u2010level filling procedures represent a safe approach for severely damaged teeth in patients receiving BPs having comparable results to root filled teeth restored with occlusal contacts and to the control group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13405","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T07:10:22Z","timestamp":1602141022000},"page":"156-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Root canal treatment of compromised teeth as alternative treatment for patients receiving bisphosphonates: 60\u2010month results of a prospective clinical study"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-4463","authenticated-orcid":false,"given":"F.","family":"Zamparini","sequence":"first","affiliation":[{"name":"Endodontic Clinical Section School of Dentistry Department of Biomedical and Neuromotor Sciences (DIBINEM) University of Bologna Bologna Italy"},{"name":"Laboratory of Green Biomaterials and Oral Pathology School of Dentistry Department of Biomedical and Neuromotor Sciences (DIBINEM) University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-6631","authenticated-orcid":false,"given":"G. 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