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Twenty\u2010one radicular cysts and 7 periapical granulomas affecting permanent teeth and 19 radicular cysts and 4 periapical granulomas affecting primary teeth were assessed for immunoglobulin (Ig) light chain (kappa and lambda), Ig heavy chain (IgG, IgG4, IgA, IgM and IgD) and plasma cell immunohistochemical markers (MUM1\/IRF4, EMA and CD138). The data acquired were analysed by Student\u2019s <jats:italic>t<\/jats:italic> test, Mann\u2013Whitney U, Friedman test followed by Dunn's multiple comparison test and Spearman\u2019s rank correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All cases were polyclonal (having similar kappa\/lambda light chain ratios). IgG was most abundant compared to other Ig heavy chains (all, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); like Ig light chains, but unlike IgA, there was greater expression of IgG in the primary compared to the permanent dentition, for both radicular cysts (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and periapical granulomas (<jats:italic>P\u00a0=\u00a00.53<\/jats:italic>). Notably, IgG4 expression was greater in the permanent than the primary dentition, for both radicular cyst (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and periapical granuloma (<jats:italic>P\u00a0=\u00a00.65<\/jats:italic>). IgM and IgD expression was scarce and variable, whereas plasma cell populations were detected efficiently through EMA, CD138 and MUM1\/IRF4 markers, the latter being more sensitive in both dentitions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were slight variations in the Ig light and heavy chain profiles in chronic periapical lesions when comparing the permanent and primary dentitions. The ability of IgG4+ plasma cell infiltration to modulate inflammatory responses in chronic periapical lesions arising from permanent as opposed to primary teeth should be considered in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13464","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T22:15:42Z","timestamp":1607638542000},"page":"682-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["IgG4\u2010positive plasma cells are more often detected in chronic periapical lesions arising from permanent rather than primary teeth"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8235-0976","authenticated-orcid":false,"given":"X. B. 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A.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School S\u00e3o Paulo State University (UNESP) Araraquara SP Brazil"},{"name":"Oral Pathology Department of Stomatology, Public Oral Health and Forensic Dentistry Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-4052","authenticated-orcid":false,"given":"L.","family":"Yamamoto de Almeida","sequence":"additional","affiliation":[{"name":"Oral Medicine Department of Diagnosis and Surgery Araraquara Dental School S\u00e3o Paulo State University (UNESP) Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-0613","authenticated-orcid":false,"given":"L. K. Y.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0230-1347","authenticated-orcid":false,"given":"R. A. B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry Ribeir\u00e3o Preto Dental School (FORP\/USP) University of S\u00e3o Paulo Ribeir\u00e3o Preto SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-6859","authenticated-orcid":false,"given":"L. A. 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