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However, many TDIs are complex, and their treatment requires a profound knowledge of the physiological and pathological responses of the affected tissues. This comprehensive review will look at the dentine\u2013pulp complex and its interaction with the surrounding tissues following TDIs. The literature up to 2020 was reviewed based on several searches on PubMed and the Cochrane Library using relevant terms. In addition to the recently revised guidelines of the International Association of Dental Traumatology, this article aims to provide background information with a focus on endodontic aspects and to gather evidence on which a clinician can make decisions on the choice of the appropriate endodontic approach for traumatized permanent teeth.<\/jats:p>","DOI":"10.1111\/iej.13508","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T09:42:22Z","timestamp":1615196542000},"page":"1221-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Endodontic management of traumatized permanent teeth: a comprehensive review"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-8121","authenticated-orcid":false,"given":"G.","family":"Krastl","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology Center of Dental Traumatology University Hospital of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Weiger","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology and Cardiology University School of Dental Medicine Basel Switzerland"},{"name":"Center of Dental Traumatology University School of Dental Medicine Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Filippi","sequence":"additional","affiliation":[{"name":"Center of Dental Traumatology University School of Dental Medicine Basel Switzerland"},{"name":"Department of Oral Surgery University School of Dental Medicine Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Van Waes","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Clinic for Orthodontics and Paediatric Dentistry University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ebeleseder","sequence":"additional","affiliation":[{"name":"University Clinic of Dental Medicine and Oral Health Medical University Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ree","sequence":"additional","affiliation":[{"name":"Private Practice Purmerend Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-5835","authenticated-orcid":false,"given":"T.","family":"Connert","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology and Cardiology University School of Dental Medicine Basel Switzerland"},{"name":"Center of Dental Traumatology University School of Dental Medicine Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7917-9466","authenticated-orcid":false,"given":"M.","family":"Widbiller","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Periodontology University Hospital Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tj\u00e4derhane","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases Helsinki University Hospital University of Helsinki Helsinki Finland"},{"name":"Research Unit of Oral Health Sciences Medical Research Center Oulu (MRC Oulu) Oulu University Hospital University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-7467","authenticated-orcid":false,"given":"P. 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