{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T07:08:45Z","timestamp":1788592125245,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>AIMS<\/jats:title>\n                    <jats:p>The European Society of Endodontology (ESE) is in the process of developing S3\u2010level clinical practice guidelines for the treatment of pulpal and apical disease. In order to support robust systematic literature reviews, appropriate outcome measures (OMs) with minimum follow\u2010up times must first be identified. Hence, the current project aimed to identify the appropriate OMs with minimum\/maximum follow\u2010up time to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of ESE S3\u2010level guidelines through a standard consensus\u2010based methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODOLOGY<\/jats:title>\n                    <jats:p>After a literature search, lists of relevant OMs were identified by the guideline development group (GDG) for the treatment of pulpitis (working group [WG] 1), the non\u2010surgical treatment of apical periodontitis (WG 2), the surgical treatment of apical periodontitis (WG 3) and the regenerative treatment of apical periodontitis (WG 4). OMs relevant to each WG were ranked by the 43\u00a0members of the GDG in their importance to the patient using a 9\u2010point Likert scale. Items with a score of 7\u20139 (critical importance) by more than 70% and items with a score of 1\u20133 (limited importance) by less than 30% of members were included, whereas the items with a score of 1\u20133 by more than 70% and items with a score of 7\u20139 by less than 30% were excluded. Several online Delphi meetings established an edited list of only important OMs. The ranked OMs were discussed by the GDG and harmonized to produce \u2018most critical\u2019, \u2018critical\u2019 and \u2018important\u2019 measures. After establishing the final ranked measures, the minimum and maximum length of follow\u2010up related to each OM was defined by the guideline steering group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The Delphi survey took place over two rounds. The patient\u2010reported outcome measure (PROM) \u2018tooth survival\u2019 was rated the \u2018most critical measure\u2019 in all four WGs, while other PROMs including \u2018pain\u2019 and \u2018need for medication\u2019 were considered \u2018critical\u2019, alongside the clinician\u2010reported outcome measures (CROM), \u2018radiographic assessment\u2019. The PROMs \u2018The need for further intervention\u2019 and \u2018oral\u2010health\u2010related\u2010quality\u2010of\u2010life\u2019 (OHRQoL) were included, but as \u2018important\u2019 not \u2018critical\u2019 measures. Differences occurred between WGs with \u2018vitality testing\u2019 defined as critical in WG1 and \u2018increased length and width of the root\u2019 defined as \u2018critical\u2019 in WG4. A minimum of 1\u2010year and maximum of \u2018as long as possible\u2019 for all OMs were deemed necessary, except \u2018pain\u2019, \u2018swelling\u2019, \u2018medication\u2019 and \u2018OHRQoL\u2019, where shorter follow\u2010up was accepted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>The GDG consensus process established the PROM \"tooth survival\" as the \"most\u2010critical\". The identified OMs and length of follow\u2010up will be applied to all the commissioned systematic reviews that will inform the subsequent process when developing the ESE S3\u2010level clinical practice guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13627","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T12:02:22Z","timestamp":1631016142000},"page":"2184-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Outcome measures to assess the effectiveness of endodontic treatment for pulpitis and apical periodontitis for use in the development of European Society of Endodontology S3\u2010level clinical practice guidelines: A consensus\u2010based development"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-2379","authenticated-orcid":false,"given":"Henry F.","family":"Duncan","sequence":"first","affiliation":[{"name":"Division of Restorative Dentistry &amp; Periodontology Dublin Dental University Hospital Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-3156","authenticated-orcid":false,"given":"Venkateshbabu","family":"Nagendrababu","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry College of Dental Medicine University of Sharjah Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7378","authenticated-orcid":false,"given":"Ikhlas","family":"El\u2010Karim","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-7467","authenticated-orcid":false,"given":"Paul M.H.","family":"Dummer","sequence":"additional","affiliation":[{"name":"School of Dentistry College of Biomedical and Life Sciences Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13516"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13501"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01180.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12629"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13080"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.09.012"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3230-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1368227"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1011024"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13290"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-132"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.13627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:15:39Z","timestamp":1693196139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.13627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,22]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/iej.13627"],"URL":"https:\/\/doi.org\/10.1111\/iej.13627","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,22]]},"assertion":[{"value":"2021-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}