{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:43:04Z","timestamp":1791927784518,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005941","name":"Dietmar Hopp Stiftung","doi-asserted-by":"publisher","award":["1DH2011152"],"award-info":[{"award-number":["1DH2011152"]}],"id":[{"id":"10.13039\/501100005941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This prospective\n                      <jats:italic>in vivo<\/jats:italic>\n                      study aimed to optimize the assessment of pulpal contrast\u2010enhancement (PCE) on dental magnetic resonance imaging (dMRI) and investigate physiological PCE patterns.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In 70 study participants, 1585 healthy teeth were examined using 3\u2010Tesla dMRI before and after contrast agent administration. For all teeth, the quotient of post\u2010 and pre\u2010contrast pulp signal intensity (Q\u2010PSI) was calculated to quantify PCE. First, pulp chambers were analysed in 10 participants to compare the coefficient of variation of mean versus maximum Q\u2010PSI values (Q\u2010PSI\n                      <jats:sub>mean<\/jats:sub>\n                      versus Q\u2010PSI\n                      <jats:sub>max<\/jats:sub>\n                      ). Second, dynamic PCE was evaluated in 10 subjects to optimize the time interval between contrast agent application and image acquisition. Finally, 50 participants (age groups: 20\u201329, 30\u201339, 40\u201349, 50\u201359 and 60\u201369\u00a0years) were examined to analyse age, gender, tooth types and maxilla versus mandible as independent factors of PCE. Statistical analysis was performed using Wilcoxon signed rank test and linear mixed models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCE assessment based on Q\u2010PSI\n                      <jats:sub>max<\/jats:sub>\n                      was associated with a significantly smaller coefficient of variation compared with Q\u2010PSI\n                      <jats:sub>mean<\/jats:sub>\n                      , with median values of 0.17 versus 0.21 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002). Analysis of dynamic PCE revealed an optimal timing interval for image acquisition 4\u00a0min after contrast media application. No significant differences in PCE were observed by comparing age groups, female versus male participants and maxillary versus mandibular teeth (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). Differences between tooth types were small (median Q\u2010PSI\n                      <jats:sub>max<\/jats:sub>\n                      values of 2.52\/2.32\/2.30\/2.20 for molars\/premolars\/canines\/incisors) but significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), except for the comparison of canines versus premolars (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.80).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PCE in dMRI was a stable intra\u2010individual marker with only minor differences between different tooth types, thus forming an important basis for intra\u2010individual controls when assessing teeth with suspected endodontic pathosis. Furthermore, it was demonstrated that PCE is independent of age, gender and jaw type. These findings indicate that dMRI\u2010based PCE analysis could be a valuable diagnostic tool for the identification of various pulp diseases in future patient studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13662","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T13:49:42Z","timestamp":1636724982000},"page":"252-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Quantitative assessment of contrast\u2010enhancement patterns of the healthy dental pulp by magnetic resonance imaging: A prospective\n                    <i>in vivo<\/i>\n                    study"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-908X","authenticated-orcid":false,"given":"Alexander","family":"Juerchott","sequence":"first","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"Jelinek","sequence":"additional","affiliation":[{"name":"Dres. Mueller\u2010Stahl Private Dental Practice  Poing Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Kronsteiner","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann M. E.","family":"Jende","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix T.","family":"Kurz","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bendszus","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Heiland","sequence":"additional","affiliation":[{"name":"Division of Experimental Radiology Department of Neuroradiology Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Hilgenfeld","sequence":"additional","affiliation":[{"name":"Department of 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