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Differences between teeth with healthy pulps versus those with irreversible pulpitis should be considered when the effects of variables are interpreted. However, there are several concerns regarding the methodology of investigations that have evaluated anaesthesia success rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several variables may influence anaesthesia success rates. There are conditions that may help to predict a patient\u2019s pain during endodontic procedures. These conditions could be overcome either by employing methods such as premedication with a non\u2010steroidal anti\u2010inflammatory drug prior to the treatment visit or by using supplementary techniques before or during the treatment. However, investigators need to be more careful when reporting details of their studies to reduce concerns regarding their study bias.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13697","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T10:54:06Z","timestamp":1643972046000},"page":"951-994","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Present status and future directions\u2014Mechanisms and management of local anaesthetic failures"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-4997","authenticated-orcid":false,"given":"Masoud","family":"Parirokh","sequence":"first","affiliation":[{"name":"Endodontology Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-4211","authenticated-orcid":false,"given":"Paul 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