{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:33:15Z","timestamp":1792477995393,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traumatic dental injuries involving the pulp are quite common and there is a need to evaluate the quality of evidence on the success of vital pulp treatment (VPT) interventions in traumatised permanent teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this systematic review was to assess the success of VPT in the management of traumatised human vital permanent teeth diagnosed with complicated crown or crown\u2010root fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search of the following databases: Web of Science, Scopus, PubMed, MEDLINE, EMBASE, LILACS, Clinical Trial Registries and the grey literature was performed until 25<jats:sup>th<\/jats:sup>\/8\/2021. Controlled clinical trials, cohort studies, case\u2010control studies, case series with at least five cases and a minimum of 12\u2010months follow\u2010up were included. Non\u2010English language literature was excluded. Two independent assessors performed study selection, data extraction and quality assessment using the National Institutes of Health\u2019s quality assessment tool. Disagreements were resolved through consensus\/with a third assessor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14\u2010studies (2\u2010controlled clinical trials, 1\u2010case\u2010control, and 11\u2010case series) published between 1978\u20132020, with a total of 1081 permanent teeth and an age range between 6\u201342\u00a0years\u2010old were included. Bias analysis ranged considerably from \u2018good\u2019 to \u2018poor\u2019. Meta\u2010analysis was not performed due to data heterogeneity, unclear reporting, and limited number of controlled clinical studies. Partial pulpotomy was the main reported clinical procedure with an overall success rate between 82.9\u2013100%. Complete pulpotomy and direct pulp capping were associated with lower success rates of 79.4\u201385.7% and 19.5%, respectively. Calcium hydroxide was the main pulp capping material with favourable clinical and radiographic success (79.4\u2013100%). Biodentine<jats:sup>\u00ae<\/jats:sup>, mineral trioxide aggregate and IRoot<jats:sup>\u00ae<\/jats:sup> BP were also associated with a high clinical and radiographic success, 80\u201391%, 80\u2013100%, and 90\u2013100%, respectively, <jats:italic>albeit<\/jats:italic> in fewer studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Although a high success rate has been reported when using VPT in managing pulpally involved traumatised teeth, the results of this systematic review clearly highlighted a paucity and low quality of the available evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall high success of VPT in the management of traumatised vital permanent teeth were reported, although based on limited evidence of well\u2010conducted clinical studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Registration<\/jats:title><jats:p>PROSPERO database (CRD42020205213).<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13741","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:10:06Z","timestamp":1648545006000},"page":"613-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Vital pulp treatment for traumatized permanent teeth: A systematic review"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1994-7002","authenticated-orcid":false,"given":"Manal","family":"Matoug\u2010Elwerfelli","sequence":"first","affiliation":[{"name":"College of Dental Medicine QU Health Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2231-5786","authenticated-orcid":false,"given":"Ahmed S.","family":"ElSheshtawy","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-5741","authenticated-orcid":false,"given":"Monty","family":"Duggal","sequence":"additional","affiliation":[{"name":"College of Dental Medicine QU Health Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7770-8259","authenticated-orcid":false,"given":"Huei Jinn","family":"Tong","sequence":"additional","affiliation":[{"name":"Discipline of Orthodontics and Paediatric Dentistry Faculty of Dentistry National University of Singapore  Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-8873","authenticated-orcid":false,"given":"Hani","family":"Nazzal","sequence":"additional","affiliation":[{"name":"College of Dental Medicine QU Health Qatar University  Doha Qatar"},{"name":"Dentistry Department Hamad Dental Centre Hamad Medical Corporation  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12553"},{"key":"e_1_2_10_3_1","first-page":"19","article-title":"Evaluation of mineral trioxide aggregate and biodentine as pulpotomy agents in immature first permanent molars with carious pulp exposure: a randomised clinical trial","volume":"22","author":"Abuelniel G.M.","year":"2021","journal-title":"European Journal of Paediatric Dentistry"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.166187"},{"key":"e_1_2_10_6_1","first-page":"102","article-title":"Epidemiology of traumatic dental injuries","volume":"35","author":"Andersson L.","year":"2013","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.04.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2010.00731.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80204-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12578"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240634"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.09.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2012.09.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13449"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(78)80153-8"},{"key":"e_1_2_10_16_1","first-page":"167","article-title":"Partial pulpotomy in crown\u2010fractured incisors\u2010results 3 to 15 years after treatment","volume":"27","author":"Cvek M.","year":"1993","journal-title":"Acta Stomatologica Croatica"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(82)80092-7"},{"key":"e_1_2_10_18_1","first-page":"358","article-title":"Guidelines for the management of traumatic dental injuries: 1. fractures and luxations of permanent teeth","volume":"38","author":"DiAngelis A.J.","year":"2016","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13080"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00610.x"},{"key":"e_1_2_10_21_1","first-page":"334","article-title":"Long\u2010term followup of traumatized incisors treated by partial pulpotomy","volume":"15","author":"Fuks A.B.","year":"1993","journal-title":"Pediatric Dentistry"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4806440"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0862-x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12424"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.01.017"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.06.003"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1983.tb01288.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203458506400410"},{"key":"e_1_2_10_29_1","first-page":"142","article-title":"Partial pulpotomy following complicated crown fracture in permanent incisors: a clinical and radiographical study","volume":"9","author":"Klein H.","year":"1985","journal-title":"The Journal of Pedodontics"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13422"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdj.2013.03.007"},{"key":"e_1_2_10_32_1","first-page":"1","article-title":"Present status and future directions \u2013 endodontic management of traumatic injuries to permanent teeth","volume":"00","author":"Krastl G.","year":"2021","journal-title":"International Endodontic Journal"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13508"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13508"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2011.01102.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02053.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.2000.00190.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4103\/jispcd.JISPCD_249_19","article-title":"Comparison between iRoot BP Plus (endosequence root repair material) and mineral trioxide aggregate as pulp\u2010capping agents: a systematic review","volume":"9","author":"Mahgoub N.","year":"2019","journal-title":"Journal of International Society of Preventive and Community Dentistry"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.07.026"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2011.01886.x"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040984"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-016-0265-5"},{"key":"e_1_2_10_44_1","volume-title":"Developing NICE guidelines: the manual","author":"NICE","year":"2014"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2012.01224.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12841"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262577"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.12.010"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33934"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12906"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2021.08.008"},{"key":"e_1_2_10_53_1","volume-title":"SIGN 50: A guideline developer\u2019s handbook","author":"SIGN 50","year":"2019"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(06)80271-2"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.05.013"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0794-1"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.12.021"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0256"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12563"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.13741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T14:20:10Z","timestamp":1692886810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.13741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,10]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/iej.13741"],"URL":"https:\/\/doi.org\/10.1111\/iej.13741","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,10]]},"assertion":[{"value":"2021-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}