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They were divided according to the experimental periods 2, 7, 14, 21 and 42\u2009days (<jats:italic>n<\/jats:italic>\u00a0=\u00a08 per group). Five animals were used as a control group (without AP). Specimens were submitted to histological processing for description of the inflammatory process, immunostaining for the presence\/absence and localization of IFI16 and IFN\u2010\u03b1\/\u03b2 receptors (qualitative and semi\u2010quantitative analysis) and tartrate\u2010resistant acid phosphatase (TRAP) histoenzimology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed a gradual development of AP over the experimental times. The expression of IFI16 was noticeably more exacerbated in the experimental early period (day 2) whilst the lowest expression was observed in the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). For IFN\u2010\u03b1\/\u03b2 receptors, a higher intensity staining was observed 42\u2009days after AP induction, that was statistically different from the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). In addition, the number of TRAP\u2010positive cells was higher on the later periods (days 21 and 42; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IFI16 protein expression was highest during the early periods after AP induction in mice teeth, whilst IFN\u2010\u03b1\/\u03b2 receptor expression was highest after AP became established.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13802","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T08:54:49Z","timestamp":1658566489000},"page":"1042-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interferon\u2010gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild\u2010type mice"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4876-6892","authenticated-orcid":false,"given":"Carolina Maschietto","family":"Pucinelli","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-4800","authenticated-orcid":false,"given":"Ricardo B.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-0613","authenticated-orcid":false,"given":"Lana K. Y.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6866-0561","authenticated-orcid":false,"given":"Marilia P.","family":"Lucisano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amily Z.","family":"C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, School of Dentistry of Ribeir\u00e3o Preto University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0610-3193","authenticated-orcid":false,"given":"Julie T.","family":"Marchesan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-6859","authenticated-orcid":false,"given":"Lea A. 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