{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:36:17Z","timestamp":1788827777681,"version":"build-2803163510"},"reference-count":67,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulpitis characterized by spontaneous pain can result in debilitating pain. Dogma has existed to offer only have two treatment options, namely root canal treatment (RCT) or extraction, although pulpotomy has always remained a potential treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review aimed to answer the following research question: \u2018Does pulpotomy (partial or full) (I) result in better patient and clinical reported outcomes (O), compared with RCT (C) in permanent teeth with pulpitis characterized by spontaneous pain (P) evaluated at various time intervals?\u2019 (T).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two authors independently performed study selection, data extraction and risk of bias assessment. The literature search was conducted in the following electronic databases: Clarivate Analytics' Web of Science, Scopus, PubMed and Cochrane Central Register of Controlled Trials. English language clinical trials comparing the patient and clinical reported outcomes between RCT and pulpotomy were included. The meta\u2010analysis was performed on a fixed\u2010effect model and the quality of evidence assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two randomized clinical trials were included. Amongst two trials, one has published four reports at different time points involving the same cohorts. The meta\u2010analysis revealed no difference in postoperative pain (Day 7) between RCT and pulpotomy (OR\u00a0=\u00a00.99, 95% CI 0.63\u20131.55,\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u20090%) and quality of evidence was graded as \u2018High\u2019. Clinical success was high at year 1, 98% for both interventions, however, decreased over time to 78.1% (pulpotomy) and 75.3% (RCT) at 5\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Pulpotomy is a definitive treatment modality that is as effective as RCT. This could have a significant impact on treatment of such patients affording the advantages of retaining a vital pulp and preventing the need for RCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review could only include two trials, hence there is insufficient evidence to draw robust conclusions. The clinical data accumulated so far suggests no difference in pain between RCT and pulpotomy at Day 7 postoperatively and a single randomized control trial suggests that the clinical success rate for both treatment modalities is similar long term. There is a need for more well\u2010designed trials by different research groups to develop a stronger evidence base in this area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>PROSPERO database (CRD42021259744).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13844","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T12:02:45Z","timestamp":1665316965000},"page":"355-369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Effectiveness of pulpotomy compared with root canal treatment in managing non\u2010traumatic pulpitis associated with spontaneous pain: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"56","author":[{"given":"Phillip L.","family":"Tomson","sequence":"first","affiliation":[{"name":"Institute of Clinical Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2062-2566","authenticated-orcid":false,"given":"Juliana","family":"Vilela Bastos","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-7269","authenticated-orcid":false,"given":"Jelena","family":"Jacimovic","sequence":"additional","affiliation":[{"name":"Central Library, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-4934","authenticated-orcid":false,"given":"Aleksandar","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-8255","authenticated-orcid":false,"given":"Shaju Jacob","family":"Pulikkotil","sequence":"additional","affiliation":[{"name":"Division of Clinical Dentistry, School of Dentistry International Medical University  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-3156","authenticated-orcid":false,"given":"Venkateshbabu","family":"Nagendrababu","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry University of Sharjah  Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.12.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.12.005"},{"key":"e_1_2_10_4_1","unstructured":"American Association of Endodontists. 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