{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:36Z","timestamp":1787318016022,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/25255\u20100"],"award-info":[{"award-number":["2016\/25255\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the influence of the early life stress (ELS) on the severity of the apical periodontitis (AP) in Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Forty male Wistar rats were divided into four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010): Control rats; AP\u2014rats with AP; ELS\u2014rats subject to ELS; AP\u2009+\u2009ELS\u2014rats exposed to ELS and subject to AP. ELS was induced by maternal separation (MS) for a period of 3\u00a0h for 21 consecutive days. AP was induced via pulp exposure of the first and second right maxillary molars to the oral environment for 40\u2009days. Three days before euthanasia, all rats underwent behavioural analysis to measure anxiety levels by elevated zero maze. Then, the rats were euthanized and the maxillas were removed to assess the occurrence and severity of AP. The periapical region was evaluated for the intensity of the inflammatory infiltrate and the extent of bone loss. The Mann\u2013Whitney test was performed for nonparametric data, and the Tukey's or Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test was performed for parametric data (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The intensity of the inflammatory infiltrate was significantly larger in the AP\u2009+\u2009ELS group when compared with AP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The AP\u2009+\u2009ELS group exhibited significantly greater alveolar bone loss, with a periapical lesion size of 103.5\u2009\u00b1\u200929.88, compared with 72.3\u2009\u00b1\u200922.28 in the AP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Rats with AP displayed higher anxiety\u2010like behaviour in relation to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). However, exposure to ELS abolished the AP\u2010induced increased anxiety\u2010like \u2018behaviour\u2019 throughout, since that rats from AP\u2009+\u2009ELS group attended more the open arms than non\u2010stressed rats with AP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early life stress is predictive of the severity of AP exacerbating the inflammatory process and increasing periapical bone resorption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13857","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T03:07:09Z","timestamp":1667185629000},"page":"203-212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early life stress exacerbates bone resorption and inhibits\u00a0anxiety\u2010like behaviour induced by apical periodontitis in rats"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-8796","authenticated-orcid":false,"given":"Maria Clara","family":"Bertolini Botelho","sequence":"first","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Psychosomatic Research Center and Oral Oncology Center, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba 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