{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:41:22Z","timestamp":1792266082423,"version":"4.4.0"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There are currently no prospective studies evaluating the long\u2010term outcomes of non\u2010surgical root canal treatments beyond 5\u2009years, both in terms of treatment success and tooth preservation, and identifying factors predictive of treatment outcome. The aim of the present work was therefore to fill this gap by assessing these outcomes over time and identifying predictive variables based on systematic data collection over a 25\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Data concerning the treatments (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u20092500) were systematically collected since 1990. Information was recorded among clinical, technical, radiographic and patient\u2010related characteristics, i.e., approximately 150 variables for each treatment. The data were analysed regarding both treatment success and tooth preservation by multivariable Cox proportional hazards model, and survival curves were generated. The statistical significance level was set at 0.0125.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 56.4% of the treatments could be followed over time (0\u201325\u2009years, mean\u00a0=\u00a06.5\u2009years, median\u00a0=\u00a05\u2009years). Survival probability decreased almost linearly for treatment success, with about 85% after 5\u2009years and 60% after 20\u2009years, and for tooth preservation, with about 90% at 5\u2009years and 50% at 20\u2009years. The variables significantly associated with treatment failure were: pre\u2010operative pain (Hazard Ratio\u2014HR\u00a0=\u00a01.56 [95% CI 1.23\u20131.97]), persistent pain (HR\u00a0=\u00a02.63 [95% CI 1.44\u20134.80]), good operator rating of treatment prognosis (HR\u00a0=\u00a00.46 [95% CI 0.36\u20130.58]), size of periapical bone radiolucency (HR\u00a0=\u00a01.88 [95% CI 1.67\u20132.11]), and tooth type (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0006). For tooth extraction, they were: combined endodontic\u2010periodontal lesion (HR\u00a0=\u00a03.37 [95% CI 1.88\u20136.05]), pre\u2010existing complication before treatment (HR\u00a0=\u00a01.67 [95% CI 1.26\u20132.21]), good operator rating of treatment prognosis (HR\u00a0=\u00a00.45 [95% CI 0.33\u20130.60]), clinical failure of root canal treatment (HR\u00a0=\u00a02.78 [95% CI 1.98\u20133.89]) and tooth type (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.0012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Root canal treatment success and tooth preservation on the arch are not static outcomes, but evolve with time. Among a substantial set of potential predictors, only a small proportion was significantly predictive of treatment success and tooth preservation, most of them being disease and patient characteristics, and not technical aspects, except pre\u2010existing complications. These observations challenge the importance frequently given to byzantine considerations related to the numerous technical details of endodontic procedures, as opposed to general concepts of good clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13895","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T04:00:04Z","timestamp":1674446404000},"page":"544-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["What ultimately matters in root canal treatment success and tooth preservation: A 25\u2010year cohort study"],"prefix":"10.1111","volume":"56","author":[{"given":"Jean Pierre","family":"Van\u00a0Nieuwenhuysen","sequence":"first","affiliation":[{"name":"Department of Adult and Child Dentistry, School of Dental Medicine Cliniques Universitaires St Luc, UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9412-0262","authenticated-orcid":false,"given":"William","family":"D'Hoore","sequence":"additional","affiliation":[{"name":"Institute of Health and Society (IRSS), UCLouvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-0019","authenticated-orcid":false,"given":"Julian G.","family":"Leprince","sequence":"additional","affiliation":[{"name":"Department of Adult and Child Dentistry, School of Dental Medicine Cliniques Universitaires St Luc, UCLouvain  Brussels Belgium"},{"name":"DRIM Research Group, Advanced Drug Delivery and Biomaterials Louvain Drug Research Institute (LDRI), UCLouvain  Brussels Belgium"},{"name":"Division of Cariology &amp; Endodontology University Clinics of Dental Medicine  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00563.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.11.022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034521990314"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12138"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/etp.12065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55293-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200212000-00007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12590"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01180.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1991.tb00162.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0503-9"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345990780070801"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000261574"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509336530"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01434.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2022.02.008"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13124"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41207-z"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.01.014"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02040.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57250-5_6"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12395"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.10.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12372"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13325"},{"key":"e_1_2_11_27_1","volume-title":"Guideline on the prudent prescription of antibiotics in the dental office. 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