{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:38Z","timestamp":1789016318600,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500845"],"award-info":[{"award-number":["81500845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970926"],"award-info":[{"award-number":["81970926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study was to explore the involvement of oxidative stress (OS) in the hepatic inflammation induced by apical periodontitis (AP). Periapical, systemic and hepatic reaction to AP under hyperlipidaemia was also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A total of 16 male Sprague\u2013Dawley rats were fed with a hyperlipidaemic diet (HD) whereas another 16 rats with a normal diet (ND). After 9\u2009weeks, the first molars of the right maxilla and mandible of 8 HD and 8 ND rats were exposed to induce AP (ND, ND\u2009+\u2009AP, HD and HD\u2009+\u2009AP group). After 5\u2009weeks, rats were euthanized, the haematological tissue was collected directly from the heart, and serum levels of inflammatory cytokines were measured. Liver tissue was analysed by haematoxylin\u2013eosin and Masson staining, and reverse transcription\u2013polymerase chain reaction (RT\u2010PCR) was performed to detect mRNA expression of inflammatory cytokines. Serum, periapical, and hepatic OS parameters including total oxidant status (TOS), total antioxidant capacity (TAOC) and oxidative stress index (OSI) were measured by enzyme\u2010linked immunosorbent assay (ELISA). The area of AP lesion in the right maxilla or mandible was radiographically assessed. Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test was performed on the periapical data. A one\u2010way analysis of variance and the Kruskal\u2013Wallis test were analysed for others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HD\u2009+\u2009AP group had a larger AP lesion in the maxilla, compared with the ND\u2009+\u2009AP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The ND\u2009+\u2009AP group presented higher serum interleukin (IL)\u201018, IL\u20101\u03b2, TOS, OSI levels, lower serum TOAC levels, higher hepatic tumour necrosis factor (TNF)\u2010\u03b1 mRNA expression and higher hepatic TOS, and OSI levels, compared with the ND group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The HD\u2009+\u2009AP group had lower serum IL\u20104 level, higher serum IL\u20101\u03b2 level, and higher hepatic IL\u20106 and transforming growth factor (TGF) \u2010\u03b21 mRNA expression, compared with the HD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Apical periodontitis could activate systemic and liver inflammation by promoting serum IL\u201018, 1L\u20101\u03b2, TOS and OSI expression, enhancing hepatic TOS and OSI expression and inhibiting serum TOAC expression. AP under hyperlipidaemia led to more profound periapical bone destruction in the maxilla and elicit systemic and liver inflammatory responses through elevating serum levels of IL\u20101\u03b2, descending serum IL\u20104 level and improving hepatic IL\u20106 and TGF\u2010\u03b21 expression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13907","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T03:03:42Z","timestamp":1677207822000},"page":"722-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Is oxidative stress involved in the hepatic inflammatory response to apical periodontitis? A comparative study in normal and hyperlipidaemic rat"],"prefix":"10.1111","volume":"56","author":[{"given":"Suli","family":"Xiao","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial\u00a0&amp; Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Institute of Stomatology, Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-7128","authenticated-orcid":false,"given":"Huaxiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases &amp; Fujian Provincial Engineering Research Center of Oral Biomaterial\u00a0&amp; Stomatological Key lab of Fujian College and University, School and 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