{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:41:26Z","timestamp":1792266086623,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2020QH1130"],"award-info":[{"award-number":["2020QH1130"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This clinical study was undertaken to assess the effect of treatment with regenerative endodontic procedures (REPs) on 20 teeth with pulp necrosis, apical periodontitis, and external root resorption (ERR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Teeth were treated with REPS utilizing the American Association of Endodontists (AAE) protocol. Quantitative assessment of changes in radiographic root area (RRA) were statistically analysed to assess changes in root dimensions after an average follow\u2010up period of 3\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 20 teeth survived, 14 teeth (70%) were classified successful, and only 1 tooth (5%) failed throughout the study period. Based on the radiographic examination, all 20 teeth showed complete repair of the periapical lesions and arrested ERR. However, 5 teeth (25%) subsequently developed replacement resorption. The RRA between baseline and 3\u2010year follow\u2010up showed a significant difference for the total 20 teeth (<jats:italic>p<\/jats:italic>\u2009=\u2009.009). An analysis according to the trauma type and the extra\u2010oral time showed the RRA increase was significantly different in the non\u2010avulsion group (<jats:italic>p<\/jats:italic>\u2009=\u2009.015) and for the avulsion group with an extra\u2010oral time less than 60\u2009min (<jats:italic>p<\/jats:italic>\u2009=\u2009.029). The RRA increase was not statistically significant in the avulsion group of extra\u2010oral time more than 60\u2009min (<jats:italic>p<\/jats:italic>\u2009=\u2009.405). Nine teeth (45%) and 10 teeth (50%) responded to cold and electric pulp testing, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limitations of this study, the favourable outcomes of REPs were further confirmed for traumatized permanent necrotic teeth with ERR in terms of periapical lesion healed and a significant increase in RRA. The study contributes further evidence of the role of REPs in arresting ERR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13919","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:26:18Z","timestamp":1680499578000},"page":"802-818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical and radiographic outcomes of regenerative endodontic procedures for traumatized permanent necrotic teeth with apical periodontitis and external root resorption"],"prefix":"10.1111","volume":"56","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youguang","family":"Lu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojie","family":"Lu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Kahler","sequence":"additional","affiliation":[{"name":"School of Dentistry University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/edt.12659"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.02.016"},{"key":"e_1_2_11_4_1","unstructured":"American Association of Endodontists. 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