{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:46:54Z","timestamp":1766760414422,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate two\u2010 and three\u2010dimensionally the effect of resorbable collagen\u2010based bone\u2010filling material on periapical healing of endodontic lesions with four\u2010wall defects following endodontic microsurgery (EMS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This parallel, randomized controlled superiority clinical trial involved 86 lesions with the strictly endodontic origin and four\u2010wall defect morphology. EMS procedures were performed by calibrated postgraduate residents. Before flap closure, osteotomies were randomized to the control or treatment group. In the control group, the flap was repositioned with no material added. In the treatment group, a collagen\u2010based bone\u2010filling augmentation material was placed into the osteotomy. Clinical and radiographic examinations were completed after 12\u2009months. Periapical healing was evaluated by blinded evaluators using periapical (PA) radiographs according to Molven's criteria and cone beam computed tomography (CBCT) scans according to PENN's 3D criteria. Cortical plate healing was scored according to the RAC\/B index. The data were analysed using Fisher's exact test, Logistic regression models and Chi\u2010squared test. The significance level was predetermined at <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six cases were evaluated at the 12\u2010month follow\u2010up, with 30 and 36 cases in the control and treatment groups, respectively. Only the asymptomatic cases (control\u2009=\u200926, treatment\u2009=\u200932) were included in the radiographic evaluation. Twenty\u2010three cases (88.5%) in the control and 28 (87.5%) cases in the treatment group demonstrated complete healing on PA radiographs (<jats:italic>p<\/jats:italic>\u2009=\u20091.000). On CBCT, 10 (38.4%) and 21 (65.6%) cases had completely healed in the control and treatment groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.095). The re\u2010establishment of the buccal cortical plate was detected in 12 (46.2%) and 22 (68.8%) cases in the control and treatment groups, respectively (<jats:italic>p<\/jats:italic>\u2009=\u2009.243).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the limitations of the present study, the use of collagen\u2010based bone\u2010filling material had no statistically significant effect on the periapical healing of endodontic lesions with four\u2010wall defect following EMS at the 12\u2010month follow\u2010up when evaluated by PA radiographs or CBCT scans. However, the observed higher percentage of a re\u2010established cortical plate in the treatment group could suggest a clinical benefit that is of interest after surgical endodontic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.13973","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T14:54:56Z","timestamp":1694444096000},"page":"1446-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Periapical healing following endodontic microsurgery with collagen\u2010based bone\u2010filling material: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6068-6089","authenticated-orcid":false,"given":"Amenah","family":"Albagle","sequence":"first","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meetu R.","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel I.","family":"Kratchman","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Karabucak","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dental Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-10-40"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1239842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13419"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.01.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.11.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.10.007"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.06.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.39"},{"key":"e_1_2_10_10_1","first-page":"51","article-title":"Efficacy of healing process of bone defects after apicectomy: results after 6 and 12 months","volume":"60","author":"Dominiak M.","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200207000-00003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.03.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.131353"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3353\/omp.15.15"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-012-0376-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.01.023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.12.010"},{"key":"e_1_2_10_18_1","first-page":"52","article-title":"The effect of tooth extraction alveolus healing by atelocollagen sponge implantation","volume":"10","author":"Kitsugi D.","year":"1997","journal-title":"Journal of Japanese Society of Oral Implantology"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20170210"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13440"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(87)80080-2"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13294"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13434"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13098"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2001.00369.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.1995.tb00155.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.03.014"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.02.007"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.08.007"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.014"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2393"},{"key":"e_1_2_10_32_1","first-page":"265","article-title":"Efficacy of guided tissue regeneration in the management of through\u2010through lesions following surgical endodontics: a preliminary study","volume":"28","author":"Taschieri S.","year":"2008","journal-title":"The International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.022"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2591.2002.00523.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.11.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12548"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.08.008"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym8040115"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.13973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:56:05Z","timestamp":1728291365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.13973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/iej.13973"],"URL":"https:\/\/doi.org\/10.1111\/iej.13973","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"type":"print","value":"0143-2885"},{"type":"electronic","value":"1365-2591"}],"subject":[],"published":{"date-parts":[[2023,9,11]]},"assertion":[{"value":"2023-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}