{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:04Z","timestamp":1787014324104,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the study was to assess the tolerance to the new root canal irrigation fluid RISA after root canal treatment (RCT) by evaluating the subject's postoperative well\u2010being, postoperative pain (PP) and treatment outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A single\u2010arm prospective study with 16 subjects (17 teeth) diagnosed with asymptomatic apical periodontitis. Endodontic treatment in one session performed using RISA for root canal irrigation. Well\u2010being was assessed on the same day and after 24\u2009h by telephone. For pain intensity, a visual analogue scale was used at 0\u20135\u2009days. Clinical and radiographic evaluations were performed at \u226512\u2009months. Well\u2010being, occurrence of PP and outcome were qualitatively reported. Friedman test for paired samples and Spearman correlation coefficient were used. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the same day and after 24\u2009h, 14\/16 subjects felt \u2018good\u2019. 9\/16 presented intra\u2010 or extra\u2010oral swelling. The frequency of PP \u226536 (weak) was 82.4%. On the same day, 1 and 2\u2009days postoperatively, there was more pain compared with preoperative pain\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05. At Day 3, PP equalled preoperative pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). 62.5% of subjects needed analgesics Day 0\u20132. The recall rate was 94.1%, and resolution of apical periodontitis was observed in 87.5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The well\u2010being of subjects was good, and the overall PP intensity was low. However, postoperative intra\u2010 and extra\u2010oral swelling occurred often. At the recall visit, the effectiveness of the RCT with RISA appeared high (87.5%). The encouraging outcome results plus the fact that RISA has a broader action range than NaOCl\n                      <jats:italic>in vitro<\/jats:italic>\n                      , justify further work on the RISA solution. To reduce postoperative swelling, it is advised to further investigate the optimal way of application of RISA in the laboratory before clinical application is recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13977","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:35:29Z","timestamp":1695958529000},"page":"1488-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Well\u2010being, postoperative pain and outcome after clinical application of a novel root canal irrigation fluid\u2014\n                    <scp>RISA<\/scp>\n                    \u2014in teeth with apical periodontitis: A first\u2010in\u2010human study"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-5801","authenticated-orcid":false,"given":"Jo\u00e3o 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