{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:59:30Z","timestamp":1793041170003,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Several factors influence the condition of the periapical tissues associated with root filled teeth. The primary objective of this study was to retrospectively evaluate the extent and speed of bone healing of large periapical lesions associated with nonsurgical root canal treatment or retreatment. The secondary objective was to analyse the relationship between the time to complete healing when analysed using cone beam computed tomography (CBCT) and other possible predictors that affect healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Seventy\u2010nine patients were treated during the years 2013\u20132020 with large periapical lesions of endodontic origin (10\u201315\u2009mm) as observed on intraoral periapical radiographs (IOPAR) were included. IOPAR and CBCT were available before treatment and during the follow\u2010up (IOPAR every 6\u2009months and CBCT every 12\u2009months). The volume of periapical lesions was calculated by OsiriX Lite software. Variables such as initial volume of the lesion, age, gender, type of treatment or type of root canal filling were compared to identify the differences between healed and unhealed lesions. Pearson's Chi\u2010square test was used for categorical variables, the t\u2010test for age and the Wilcoxon test for initial volume of the lesion. The association between time to healing and the variables was assessed using univariate analysis and multivariate analysis. The Wilcoxon test was used to observe the association of healing time with categorical variables and the correlation index was measured with the quantitative variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 79 cases analysed, 60 lesions (76%) were completely healed as verified by CBCT in a mean healing time of 19\u2009months, of which 60% healed fully between 12 and 18\u2009months. Increase in age of patient and larger initial volume of the lesion were associated with a significantly longer healing time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). Gender, filling material and type of treatment did not have a significant effect on the healing process (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians should be aware that periapical lesions in older patients and larger areas of bone loss take longer to heal. CBCT monitoring of large periapical lesions is critical and it can help clinicians in the decision\u2010making process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.13993","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:53:10Z","timestamp":1700193190000},"page":"23-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography\u2010based retrospective study"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2032-4681","authenticated-orcid":false,"given":"Carolina","family":"Mosquera\u2010Barreiro","sequence":"first","affiliation":[{"name":"Surgery and medical surgical specialties. International theoretical\u2010practical Master of Endodontics, Dentistry Restorative and Aesthetics University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9110-3173","authenticated-orcid":false,"given":"Manuel","family":"Ru\u00edz\u2010Pi\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Surgery and medical surgical specialties. International theoretical\u2010practical Master of Endodontics, Dentistry Restorative and Aesthetics University of Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-3039","authenticated-orcid":false,"given":"Francesc Abella","family":"Sans","sequence":"additional","affiliation":[{"name":"Department of Endodontics Universitat Internacional de Catalunya  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-3156","authenticated-orcid":false,"given":"Venkateshbabu","family":"Nagendrababu","sequence":"additional","affiliation":[{"name":"Department of Preventive and Restorative Dentistry University of Sharjah  College of Dental Medicine, Sharjah United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-3872","authenticated-orcid":false,"given":"Thilla Sekar","family":"Vinothkumar","sequence":"additional","affiliation":[{"name":"Department of Restorative Dental Sciences, Division of Operative Dentistry, College of Dentistry Jazan University  Jazan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-133X","authenticated-orcid":false,"given":"Jenifer","family":"Mart\u00edn\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Stomatology, School of Dentistry University of Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-4220","authenticated-orcid":false,"given":"Benjam\u00edn","family":"Mart\u00edn\u2010Biedma","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group, Endodontics and Restorative Dentistry Unit, School of Medicine and Dentistry University of Santiago de Compostela, Health Research Institute of Santiago de Compostela 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