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Pre\u2010operatively, data regarding patients' numerical ratings scale (NRS), pain score (0\u201310), analgesic use, oral\u2010health impact profile\u201014 (OHIP\u201014) and need for time away from work were collected. For 7\u2009days post\u2010operatively, participants recorded their NRS pain score, global rating of change score, medication use and their ability to work. Analysis used a mixed\u2010effects model with post hoc Tukey's multiple comparisons test for continuous data and chi\u2010squared or Fisher's exact test for categorical data. To test the effect of the corticosteroid\/antibiotic paste, pulpectomy and pulpotomy groups were combined following Mantel\u2013Haenszel stratified analysis or a weighted average of the difference between pulpotomy and pulpectomy with and without the use of corticosteroid\/antibiotic paste. A binary composite score was constructed using pre\u2010 and post\u2010operative data, whereby overall treatment success was defined as: (i) patients did not return for treatment due to pain by day seven; (ii) at day three, there was a 33% (or 2\u2010points) reduction in NRS pain score; (iii) there was a change score of +3 in global rating; (iv) the patient was no longer using analgesia and able to return to work.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010five participants were recruited, with 83 completing follow up. Overall treatment success was 57%, with 25% of participants returning for more treatment due to inadequate pain relief. Overall treatment success did not differ between the two groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.645), although patients self\u2010reported greater improvement with an antibiotic\/corticosteroid dressing for global rating of change (<jats:italic>p<\/jats:italic>\u2009=\u2009.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified limited evidence of improved outcomes using antibiotic\/corticosteroid dressings in the management of symptomatic irreversible pulpitis in the emergency setting. Further clinical research is needed to understand if these medications are beneficial in affording pain relief, above that of simple excision of irreversibly inflamed pulp tissue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.14020","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T08:35:27Z","timestamp":1705048527000},"page":"416-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The use of medicaments in the management of symptomatic irreversible pulpitis: A community\u2010based cohort study"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-7463","authenticated-orcid":false,"given":"David","family":"Edwards","sequence":"first","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rasaiah","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-2473","authenticated-orcid":false,"given":"Lise\u2010Lotte","family":"Kirkevang","sequence":"additional","affiliation":[{"name":"Department of Dentistry and Oral Health Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-5006","authenticated-orcid":false,"given":"Michael","family":"Vaeth","sequence":"additional","affiliation":[{"name":"Department of Public Health Aarhus University  Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Stone","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Obara","sequence":"additional","affiliation":[{"name":"School of Pharmacy Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Durham","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Whitworth","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"AAE. 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