{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T21:18:24Z","timestamp":1794086304138,"version":"4.8.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160741"],"award-info":[{"award-number":["1160741"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1200098"],"award-info":[{"award-number":["1200098"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21210509"],"award-info":[{"award-number":["21210509"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["21210551"],"award-info":[{"award-number":["21210551"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the systemic inflammatory burden, including hsCRP and its monomeric forms, in patients with apical lesions of endodontic origin treated with root canal treatment (RCT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Prospective pre\u2010\/post\u2010study. Apical periodontitis (AP) individuals aged 16\u201340 were included (<jats:italic>N<\/jats:italic>\u2009=\u200929). Individuals received RCT and were followed at 1 and 6\u2009months. Fasting blood samples were obtained. Apical lesions of endodontic origin (ALEO) diameter (mm), and periapical index (PAI), were recorded. The serum concentrations of total hsCRP were determined by turbidimetry. Tumour necrosis factor (TNF)\u2010\u03b1, interleukin (IL)\u20106, IL\u201010, IL\u20101\u03b2, and soluble (s) E\u2010selectin were assessed by Multiplex assay. Additionally, mCRP forms were determined in the serum of AP patients with a baseline moderate to high cardiovascular risk based on hsCRP stratification (hsCRP \u22651\u2009mg\/L) by immunowestern blot (<jats:italic>n<\/jats:italic>\u2009=\u200915). Also, CRP isoforms were explored in ALEOs from AP individuals (<jats:italic>n<\/jats:italic>\u2009=\u20094). Data were analysed with StataV16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periapical index and ALEO sizes were reduced at both follow\u2010up visits after RCT (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Serum levels of TNF\u2010\u03b1, IL\u20106, IL\u201010, IL\u20101\u03b2, and sE\u2010selectin did not show significant differences. CRP was borderline reduced at 1\u2009month (<jats:italic>p<\/jats:italic>\u2009=\u2009.04); however, in AP individuals at cardiovascular risk (hsCRP\u2009\u2265\u20091\u2009mg\/L), hsCRP and its monomeric isoform significantly decreased at 1 and 6\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010sensitivity CRP and mCRP are reduced after RCT in AP individuals at cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.14029","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T14:19:15Z","timestamp":1705760355000},"page":"406-415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Reduced C\u2010reactive protein levels after root canal treatment in clinically healthy young apical periodontitis individuals at cardiovascular risk. A prospective study"],"prefix":"10.1111","volume":"57","author":[{"given":"Mauricio","family":"Garrido","sequence":"first","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-6045","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Bordagaray","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-7971","authenticated-orcid":false,"given":"Catalina","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Lucero\u2010Mora","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Laboratory of Oral Biology, Faculty of Dentistry Universidad Finis Terrae  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oral Medicine, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hern\u00e1ndez\u2010R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidad Andres Bello  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-7314","authenticated-orcid":false,"given":"Marcela","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Department of Pathology and Oral Medicine, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","unstructured":"AAE(2009)Consensus Conference Recommended Diagnostic Terminology. J Endod;35 1634.","DOI":"10.1016\/j.joen.2009.09.035"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13554"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13786"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.01.018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24112062"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.861665"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14188"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1987.tb00543.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-9-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.190611"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2018.11.014"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.12.021"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.07.017"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13854"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.014"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.09.028"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12872"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2016-0464"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.05.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.07.007"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04083-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01103-9"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12076"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.883"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.02.008"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12772"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.7019"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S320659"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13318"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79300-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1986.tb00119.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060264"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13316"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13444"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02126"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.06.024"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03738-y"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13789"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1522447"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13467"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12309"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1646-6"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.14029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:20:07Z","timestamp":1735968007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.14029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,20]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/iej.14029"],"URL":"https:\/\/doi.org\/10.1111\/iej.14029","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,20]]},"assertion":[{"value":"2023-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}