{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:19:08Z","timestamp":1787725148047,"version":"build-2784847793"},"reference-count":68,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate clinical and radiographic outcome of endodontic microsurgery in through\u2010and\u2010through periapical lesions at 1\u2010year and 5\u2010year follow\u2010up with adjunct use of platelet\u2010rich plasma (PRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Thirty\u2010two patients with large through\u2010and\u2010through periapical lesions were randomized in platelet\u2010rich plasma (PRP) group and control group. Two\u2010dimensional (2D) healing was evaluated with Molven's criteria and three\u2010dimensional (3D) healing with modified PENN 3D criteria. Healing at resection plane (R), apical area (A), buccal cortex (BC), palatal cortex (PC) and overall bone healing (B) was assessed using CBCT scans. The volume of lesion was measured using ITK\u2010Snap software. The analysis included comparison of 1\u2010 to 5\u2010year intragroup (Friedman test\/McNemar test) and intergroup scoring (Chi\u2010square\/ Mann\u2013Whitney test). Logistic regression analysis was performed to determine the effect of various factors on healing at 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 32 patients\/59 teeth evaluated after 1\u2010year of endodontic microsurgery, 24 patients\/44 teeth reported at 5 \u2010 year follow\u2010up. Healing assessment with modified PENN 3D criteria revealed improvement in overall success rate of 66.7% at 1 year to 83.3% at 5\u2009years, with no deterioration in any healing category. PRP group exhibited significantly better 3D healing than control group; both at 1 year (84.6% vs. 45.5%) and 5\u2009years (100% vs. 63.6%). A significantly higher number of completely healed teeth were observed in PRP group than the control group at 5\u2009years with respect to R, BC and B parameters. A volume reduction of 88% (91.4% PRP, 84% control) was depicted at 1 year and 94% (97.1% PRP, 91.1% control) at 5\u2009years. None of the recorded factors including age, gender, size of lesion, preoperative swelling and sinus, histology of lesion, use of PRP, tooth location, preoperative buccal bone had significant effect on 3D healing at 5\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This 5\u2010year study suggested improvement in 3D radiographic healing of large through\u2010and\u2010through periapical lesions from 1 to 5\u2009years with no deterioration in any healing parameter in both control and PRP groups. The additional use of PRP led to significantly better healing in such lesions. RACB index using CBCT allows better estimation of healing at resected, apical and cortical plane over modified PENN 3D or Molven's criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.14084","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:14:21Z","timestamp":1715944461000},"page":"1180-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<scp>Two\u2010<\/scp>\n                    and\n                    <scp>three\u2010dimensional<\/scp>\n                    healing assessment after endodontic microsurgery in through\u2010and\u2010through periapical lesions: 5\u2010year follow\u2010up from a randomized controlled trial"],"prefix":"10.1111","volume":"57","author":[{"given":"Ritika","family":"Dhamija","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Post Graduate Institute of Dental Sciences  Rohtak 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