{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:52:15Z","timestamp":1787169135968,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010751","name":"Fondo Nacional de Desarrollo Cient\u00edfico, Tecnol\u00f3gico y de Innovaci\u00f3n Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["1160741 and 1200098"],"award-info":[{"award-number":["1160741 and 1200098"]}],"id":[{"id":"10.13039\/501100010751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Apical periodontitis (AP) is the chronic inflammation of the periradicular tissues in response to root canal infection. Whilst AP has been linked with systemic inflammation and noncommunicable diseases, its potential association with nonalcoholic fatty liver disease (NAFLD) is unknown. We aimed to evaluate the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels as surrogate markers of hepatic injury, and the systemic inflammatory burden in otherwise healthy individuals with and without AP diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectional study. Individuals with AP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) were recruited. The number, mean diameter (mm) and periapical index of the apical lesions of endodontic origin (ALEO) were assessed. ALT and AST levels (pg\/mL) were measured through enzyme\u2010linked immunosorbent assays. The serum levels of TNF\u2010\u03b1, IL\u20104, IL\u20109, IL\u201010, IL\u201017A and IL\u201022 were evaluated by Multiplex assay. Inferential analysis was performed using\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Mann\u2013Whitney tests according to data distribution and linear regression models. Data were analysed with StataV16 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ALT and AST levels were significantly higher in individuals with AP compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Serum inflammatory biomarkers showed no significant differences between the study groups. Bivariate and multivariate analyses confirmed that AP diagnosis was independently associated with ALT and AST elevations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Additionally, the number of ALEO positively influenced AST levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002). IL\u201022 on the other hand, was associated with reduced ALT levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AP is associated with higher serum hepatic transaminases ALT and AST, potentially contributing to NAFLD physiopathology in young adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.14109","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:50:20Z","timestamp":1718182220000},"page":"1395-1403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated serum hepatic transaminases in apical periodontitis individuals"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-6045","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Bordagaray","sequence":"first","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"},{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hern\u00e1ndez\u2010R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Villalobos","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidad Andres Bello  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-7314","authenticated-orcid":false,"given":"Marcela","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratory of Periodontal Biology, Faculty of Dentistry 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