{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:46Z","timestamp":1789016326173,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study investigated the influence of apical periodontitis (AP) on the severity of rheumatoid arthritis (RA) using a Wistar rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Forty male Wistar rats were distributed across four groups (<jats:italic>n<\/jats:italic>\u2009=\u200910) based on the induction of RA and AP: Control, RA, AP, and RA\u2009+\u2009AP. RA was induced through two immunisations with type II collagen emulsified in incomplete Freund's adjuvant, followed by one immunisation with complete Freund's adjuvant. After 21\u2009days of RA induction, AP was induced by exposing the pulp of four molars. Animals were euthanized after 28\u2009days of pulp exposure. Through the experiment, visual and behavioural assessments tracked RA development and the knees and hind paw joints were measured. Micro\u2010computed tomography scans of knees and hind paws, as well as mandibles and maxillae, were conducted to evaluate RA severity and the presence of AP, respectively. Serum samples were collected to analyse proinflammatory cytokines (IL\u20101\u03b2, IL\u20102, IL\u201017, and TNF\u2010\u03b1). Non\u2010parametric data were analysed using the Kruskal\u2010Wallis test followed by Student\u2013Newman\u2013Keuls test, while one\u2010way <jats:sc>anova<\/jats:sc> followed by Tukey's test was performed for parametric data. A significance level of 5% was employed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All molars submitted to access cavity developed AP. All joints subjected to arthritis induction developed the disease, with AP\u2009+\u2009RA demonstrating a higher arthritis severity when compared to the RA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). RA\u2009+\u2009AP group displayed a significantly larger hind paw and knee circumference compared to the RA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Micro\u2010CT images of RA and RA\u2009+\u2009AP groups revealed joints with erosions and bone deformities, with a significantly lower bone surface density, lower trabecular number and higher trabecular separation in the hind paw and a significantly lower percent bone volume and higher trabecular separation in the knees of RA\u2009+\u2009AP group compared to RA group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). RA\u2009+\u2009AP group exhibited a significantly higher level of TNF\u2010\u03b1 and a lower level of IL\u20102 compared to all other groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Both RA and RA\u2009+\u2009AP groups had significantly higher IL\u201017 levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05), while there was no significant difference in IL\u20101\u03b2 levels among the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings from this study underscore a possible relationship between apical periodontitis and the exacerbation of rheumatoid arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.14130","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T03:52:21Z","timestamp":1722397941000},"page":"1669-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Apical periodontitis as an aggravating factor for the severity of rheumatoid arthritis: An animal study"],"prefix":"10.1111","volume":"57","author":[{"given":"Bianca Ara\u00fajo Magalh\u00e3es","family":"Damiani","sequence":"first","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-9541","authenticated-orcid":false,"given":"Karem Paula","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-3757","authenticated-orcid":false,"given":"Cl\u00e1udio Malizia Alves","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9411-7151","authenticated-orcid":false,"given":"Est\u00e9fano Borgo","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-4373","authenticated-orcid":false,"given":"Carolina Oliveira","family":"de Lima","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Juiz de Fora, Campus Governador Valadares  Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-5197","authenticated-orcid":false,"given":"Caroline Silva","family":"Cassimiro","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-7490","authenticated-orcid":false,"given":"Luciana Moura","family":"Sassone","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8243","authenticated-orcid":false,"given":"Emmanuel Jo\u00e3o Nogueira Leal","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Integrated Clinical Procedures, School of Dentistry Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"},{"name":"Departament of Endodontics Grande Rio University (UNIGRANRIO)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.03.024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10389-019-01073-5"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13902"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01664"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.04.028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12300"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/569068"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016357.2018.1521005"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520952341"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.01.022"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174442"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2010.07.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155956"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20103042"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-31696-5.00069-3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.02.006"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.09.022"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20108993(99)01186\u20105"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.07.017"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.06.014"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-2121-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102020\u2010219247"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.78"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201801979"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aej.12072"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.02.015"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010020\u201002253\u20105"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03026336"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296\u2010011\u20102284\u20101"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2019.52824"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05970"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19\u20100311"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.13.4.547\u2010558.2000"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.10371"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010010\u20109250\u2010z"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009747509165253"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.03.020"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20103682\u20104_1"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807\u20103107bor\u20102017.vol31.0103"},{"key":"e_1_2_12_42_1","doi-asserted-by":"crossref","unstructured":"Panezai J. Ali A. Ghaffar A. Benchimol D. Altamash M. Klinge B.et\u00a0al. (2020)Upregulation of circulating inflammatory biomarkers under the influence of periodontal disease in rheumatoid arthritis patients.www.elsevier.com\/locate\/cytokine","DOI":"10.1016\/j.cyto.2020.155117"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727\u201091\u201022179"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.05.010"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.22037\/iej.v18i3.42560"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41927-020-00129-4"},{"issue":"8","key":"e_1_2_12_47_1","first-page":"6131","article-title":"Animal models of rheumatoid arthritis: correlation and usefulness with human rheumatoid arthritis","volume":"3","author":"Roy T.","year":"2013","journal-title":"Indo American Journal of Pharmaceutical Research"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010016\u20101143\u20106"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-7520-1_1"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12507"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600403"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393\u2010012\u20101083\u20108"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232\u2010020\u201000133\u20108"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0363546510378088"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2007.05.010"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947341"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753\u2010013\u20109687\u2010y"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.10.022"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13112"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12847"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.08.003"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2013.09.033"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2014.01.007"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1646-6"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.14130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T15:01:14Z","timestamp":1728572474000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.14130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/iej.14130"],"URL":"https:\/\/doi.org\/10.1111\/iej.14130","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"2024-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}