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Eligible papers were reviewed to reveal the descriptions of bone and root resorption processes. The abstracts were searched manually to identify articles about infection\u2010stimulating bone and root resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three main types of root resorption were identified, two associated with primary bacterial infection and one secondary to bacterial infection. These include external inflammatory resorption, internal inflammatory resorption and external cervical (invasive) resorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The magnitude of cytokine involvement that promotes resorption and M\u2010CSF\/RANKL production depends on multiple factors, including pathogen virulence, site of infection and host genetic factors that activate the inflammation at the infection site. Two mechanisms activate the resorption mechanisms\u2014the canonical and non\u2010canonical pathways that can activate clastic cells independently of the RANKL\/RANK canonical pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two pathways of root resorption co\u2010exist in the body. When resorption is caused by infection, chronic inflammation due to bacterial infection prolongs the secretions of pro\u2010inflammatory cytokines that intensify root and bone resorption. 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