{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:49:28Z","timestamp":1787496568693,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005760","name":"G\u00f6teborgs Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To evaluate the 6\u2010year outcome of root canal treatment irrigated with 0.5% or 3% sodium hypochlorite (NaOCl).<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n \n The baseline trial was designed as a quasi\u2010randomized clinical trial. Patients referred for root canal treatment to an endodontic specialist clinic were recruited to the study (\n n<\/jats:italic>\n \u2009=\u2009298). The concentration of NaOCl was allocated quasi\u2010randomized to 271 subjects (0.5% [\n n<\/jats:italic>\n \u2009=\u2009139], 3% [\n n<\/jats:italic>\n \u2009=\u2009132]). Bacterial sampling was performed immediately before root canal filling. Samples were cultured and evaluated as growth or no growth. Patients were invited to a clinical and radiological follow\u2010up >5\u2009years postoperatively. The clinical outcome measurements were tooth survival, cumulative incidence of endodontic retreatments, patients' assessment of pain, clinical findings and radiological signs of apical periodontitis (AP).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Tooth survival was 85.6% in the 0.5% NaOCl group and 81.1% in the 3% NaOCl group (\n p<\/jats:italic>\n \u2009=\u2009.45). There was no record of retreatment in 94.4% in the 0.5% NaOCl group and in 92.2% in the 3% NaOCl group (\n p<\/jats:italic>\n \u2009=\u2009.76). The percentage of asymptomatic cases were 87.8% in the 0.5% group and 85.3% in the 3% NaOCl group (\n p<\/jats:italic>\n \u2009=\u2009.81). Absence of clinical signs of AP was seen in 86.6% in the 0.5% NaOCl group and in 83.6% in the 3% NaOCl group (\n p<\/jats:italic>\n \u2009=\u2009.80). Absence of radiological signs of AP was seen in 74.0% in the 0.5% NaOCl group and 64.1% in the 3% NaOCl group (\n p<\/jats:italic>\n \u2009=\u2009.20). Subjects with positive culture before root filling reported subjective pain with a significantly higher frequency as compared to negative\u2010culture subjects (\n p<\/jats:italic>\n \u2009=\u2009.014).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The use of 0.5% or 3% NaOCl for irrigation during root canal treatment resulted in similar clinical outcomes 5\u20137\u2009years postoperatively. Persisting bacteria immediately before root filling may predict future episodes of subjective pain.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/iej.14134","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T09:44:30Z","timestamp":1723455870000},"page":"1745-1757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The use of 0.5% or 3%\n N<\/scp>\n a\n OCl<\/scp>\n for irrigation during root canal treatment results in similar clinical outcome: A 6\u2010year follow\u2010up of a quasi\u2010randomized clinical trial"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5212-2005","authenticated-orcid":false,"given":"Arvid","family":"Dahlstrand Rudin","sequence":"first","affiliation":[{"name":"Department of Endodontology Institute of Odontology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Public Dental Service, V\u00e4stra G\u00f6talandsregionen Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-8645","authenticated-orcid":false,"given":"Agnes","family":"Dahlstrand Rudin","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology and Immunology Institute of Odontology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7492-0924","authenticated-orcid":false,"given":"Charlotte","family":"Ulin","sequence":"additional","affiliation":[{"name":"Public Dental Service, V\u00e4stra G\u00f6talandsregionen Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-3656","authenticated-orcid":false,"given":"Thomas","family":"Kvist","sequence":"additional","affiliation":[{"name":"Department of Endodontology Institute of Odontology, Sahlgrenska Academy at University of Gothenburg Gothenburg Sweden"},{"name":"Public Dental Service, V\u00e4stra G\u00f6talandsregionen Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13739"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.113106"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2005.07.002"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119080343.ch4"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2011.08.013"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-0707.117486"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13897"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12650"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13020"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.10.002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2007.07.005"},{"key":"e_1_2_14_13_1","first-page":"1","article-title":"Microbiological examination of root canals and periapical tissues of human teeth. 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