{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:03:16Z","timestamp":1791961396786,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized clinical trial assessed the outcomes of nonsurgical root canal treatment (RCT), comparing a calcium silicate\u2010based sealer (CSBS) with the single\u2010cone technique (SC) with a zinc oxide\u2010eugenol (ZOE) sealer and warm vertical compaction (WVC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Ninety\u2010two single\u2010 and multi\u2010rooted teeth were divided into two groups and treated using either the SC with BioRoot\u2122 RCS (BIO) or WVC with Pulp Canal Sealer\u2122 EWT (PCS). Teeth with apical periodontitis (AP) in both groups were further divided into BIOAP and PCSAP subgroups. Standardized instrumentation and disinfection protocols were followed. Periapical index (PAI) was recorded, and clinical and radiographic follow\u2010ups were conducted at 1, 3, 6, 12, 24, and 48\u2009months. Outcomes considered included success rate (under strict and loose criteria), extraction, length of filling, voids, and extrusion rate, as well as changes in PAI score from baseline. Outcome variables and prognostic factors were analysed using binary and multiple logistic regression at <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010seven teeth were included (recall rate, 73%). At 4\u2010year follow\u2010up, the overall success rates (BIO\u2009+\u2009PCS) were 89.6% by loose criteria and 83.3% by strict criteria. Subgroup success rates (BIOAP+PCSAP) were 88.5% by loose criteria and 80.4% by strict criteria. There were no significant differences between the groups in terms of success rate, extraction rate, length of filling, voids, or extrusion (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). The pattern of PAI reduction was similar in both groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.806).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Treatment using the SC\u2010CSBS technique and the ZOE sealer with the WVC technique demonstrated a similar success rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.14167","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T11:29:17Z","timestamp":1733830157000},"page":"193-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A 4\u2010year follow\u2010up of root canal obturation using a calcium\u00a0silicate\u2010based sealer and a zinc oxide\u2010eugenol sealer: A\u00a0randomized clinical trial"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-8597","authenticated-orcid":false,"given":"Giulia","family":"Bardini","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1303-3787","authenticated-orcid":false,"given":"Montse Mercade","family":"Bellido","sequence":"additional","affiliation":[{"name":"Department of Dentistry University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Rossi\u2010Fedele","sequence":"additional","affiliation":[{"name":"Adelaide Dental School, University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Casula","sequence":"additional","affiliation":[{"name":"AOU Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Dettori","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ideo","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-5410","authenticated-orcid":false,"given":"Elisabetta","family":"Cotti","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics University of Cagliari  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Canal preparation and obturation: an updated view of the two pillars of nonsurgical endodontics","author":"AAE","year":"2016"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.07.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.06.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.09.019"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003590\u20100"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma15103501"},{"key":"e_1_2_12_8_1","volume-title":"Cohen's pathways of the pulp expert consult","author":"Berman L.","year":"2015"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.06.021"},{"key":"e_1_2_12_10_1","first-page":"80","article-title":"The continuous wave of condensation technique: a convergence of conceptual and procedural advances in obturation","volume":"13","author":"Buchanan L.S.","year":"1994","journal-title":"Dentistry Today"},{"key":"e_1_2_12_11_1","first-page":"90","article-title":"Endodontic obturation techniques. 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