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However, angiogenesis and neurogenesis for functional pulp regeneration have not yet met the standard for large\u2010scale clinical application, and need further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review focused on the potential mechanisms of angiogenesis and neurogenesis in pulp regeneration, including stem cell types, upstream and downstream regulatory molecules and cascade signalling pathways, thereby providing a theoretical basis and inspiring new ideas to improve the effectiveness of dental pulp tissue engineering.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic literature search was carried out using the keywords of \u2018pulp regeneration\u2019, \u2018stem cell transplantation\u2019, \u2018dental pulp stem cells\u2019, \u2018angiogenesis\u2019 and \u2018neurogenesis\u2019. The resulting literature was screened and reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stem cells used in dental pulp tissue engineering can be classified as dental\u2010derived and non\u2010dental\u2010derived stem cells, amongst which dental pulp stem cells (DPSC) have achieved promising results in animal experiments and clinical trials. Multiple molecules and signalling pathways are involved in the process of DPSC\u2010mediated angiogenic and neurogenetic regeneration. In order to promote angiogenesis and neurogenesis in pulp regeneration, feasible measures include the addition of growth factors, the modulation of transcription factors and signalling pathways, the use of extracellular vesicles and the modification of bioscaffold materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dental pulp tissue engineering has had breakthroughs in preclinical and clinical studies in\u00a0vivo. Overcoming difficulties in pulpal angiogenesis and neurogenesis, and achieving functional pulp regeneration will lead to a significant impact in endodontics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iej.14180","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T12:19:59Z","timestamp":1733919599000},"page":"391-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Angiogenic and neurogenic potential of dental\u2010derived stem cells for functional pulp regeneration: A narrative review"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1233-1544","authenticated-orcid":false,"given":"Wanting","family":"Su","sequence":"first","affiliation":[{"name":"School of Stomatology Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chufang","family":"Liao","sequence":"additional","affiliation":[{"name":"School of 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