{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:25:35Z","timestamp":1788672335215,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312275\/2021\u20108"],"award-info":[{"award-number":["312275\/2021\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of a\u00e7ai on bone and systemic damage caused by apical periodontitis (AP) in an animal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In this experimental study, 32 male Wistar rats were randomly allocated into six groups\u2014Control 14\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), Control 28\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), AP 14\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), AP 28\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094), AP plus a\u00e7ai treatment for 14\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) and AP plus a\u00e7ai treatment for 28\u2009days (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098). Apical periodontitis was induced under general anaesthesia by exposing the pulp of the first molars to the oral environment. Daily treatments were administered by gavage at a dose of 0.01\u2009mL\/g, using either saline solution or clarified a\u00e7ai. At the end of each experimental period, periapical lesions were quantitatively evaluated by micro\u2010computed tomography (micro\u2010CT) and histopathological analyses, whilst systemic oxidative stress was assessed through biochemical assays. Data normality was verified using the Shapiro\u2013Wilk test, followed by one\u2010way\n                      <jats:sc>anova<\/jats:sc>\n                      and Tukey's post hoc test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Micro\u2010CT analysis revealed that a\u00e7ai reduced apical periodontitis lesion volume and improved bone quality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Histopathological evaluation corroborated these findings, revealing moderate inflammation at 14\u2009days and more pronounced, heterogeneous inflammatory responses at 28\u2009days, with no significant differences between groups. Additionally, a\u00e7ai modulated systemic oxidative biochemistry, enhanced antioxidant defences and reduced pro\u2010oxidant damage after 28\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oral a\u00e7ai administration was associated with reduced progression of apical periodontitis and improved bone quality, suggesting its potential as a protective antioxidant in endodontic treatment, minimizing both local and systemic damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.14247","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:16:05Z","timestamp":1748337365000},"page":"1211-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of alveolar bone preservation and oxidative stress reduction with a\u00e7ai in 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