{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:20:38Z","timestamp":1791822038753,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Determine the reliability and clinical validity of the Wolters classification of pulpitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Prospective diagnostic accuracy study in which patients with pulpitis were included. Based on history, clinical and radiographic examination, participants were categorized into initial, mild, moderate or severe pulpitis based on Wolters classification and received treatment as suggested in the classification. The American Association of Endodontists (AAE) classification was used for comparison. Treatment outcome was evaluated at 12\u2009months. Classification reliability was assessed by measuring the interrater agreement using Fleiss' Kappa. Construct validity was assessed by cluster analysis using an unsupervised machine learning approach. Predictive validity was determined by the association of treatment outcome with the diagnostic category. All statistical analyses were conducted using R v4.3.1; a\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of &lt;.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010two patients were included in the study. The interrater reliability showed fair agreement for Wolters classification (Kappa (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      )\u2009=\u20090.593, 95% confidence interval (CI): 0.592\u20130.595), compared with substantial agreement (\n                      <jats:italic>\u03ba<\/jats:italic>\n                      \u2009=\u20090.888, 95% CI: 0.887\u20130.889) for the AAE classification. Association of Wolters classification with output of unsupervised K\u2010mode cluster analysis showed that the use of a three\u2010category model may improve discrimination of pulpitis subdivided into mild, moderate, and severe categories. The revised classification model demonstrated 100% sensitivity and specificity for accurate discrimination between mild and severe pulpitis and 83% sensitivity and 85.7% specificity for classifying moderate pulpitis. There was no significant difference between these revised diagnostic categories considering treatment outcome, suggesting good predictive validity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.05). Compared with the AAE classification, the new classification in conjunction with proposed treatments resulted in preserving 87% of the pulps compared with historical treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We propose that a revised Wolters classification model is suitable for determining mild, moderate, and severe pulpitis to aid in clinical management of pulpitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.14254","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T10:46:34Z","timestamp":1748342794000},"page":"1158-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical validation of a proposed diagnostic classification for pulpitis"],"prefix":"10.1111","volume":"58","author":[{"given":"R. N.","family":"Karrar","sequence":"first","affiliation":[{"name":"Faculty of Dentistry University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-751X","authenticated-orcid":false,"given":"S. G.","family":"Craig","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-2379","authenticated-orcid":false,"given":"H. F.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry &amp; Periodontology Dublin Dental University Hospital, Trinity College Dublin, University of Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Abushouk","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Y.","family":"Elfiel","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Khartoum  Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-1150","authenticated-orcid":false,"given":"F. T.","family":"Lundy","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-7257","authenticated-orcid":false,"given":"M.","family":"Clarke","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7378","authenticated-orcid":false,"given":"I. 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