{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:45:38Z","timestamp":1791549938915,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Numerous studies have reported favourable outcomes following complete pulpotomy (CP) and partial pulpotomy (PP) in cariously exposed mature permanent teeth with symptomatic irreversible pulpitis (SIP) at 1\u2010year follow\u2010up. However, literature on long\u2010term outcomes is sparse. The European Society of Endodontology and the American Association of Endodontists emphasised the need for long\u2010term evidence before establishing pulpotomy as a definitive treatment. This prospective follow\u2010up study aimed to compare 5\u2010year outcomes of CP and PP performed in such teeth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      This prospective study followed participants from a previously published superiority randomised trial on CP and PP for managing cariously exposed mature permanent teeth with SIP. The original trial was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT04397315). Ninety\u2010three participants (CP\u201449, PP\u201444) received the allocated intervention. Of these, 88 (CP\u201445, PP\u201443) participants who attended the 1\u2010year follow\u2010up were recalled for the 5\u2010year follow\u2010up. The primary outcome was combined clinical and radiographic success. Secondary outcome measures included hard tissue barrier (HTB) formation and pulp canal obliteration (PCO). Cases were analysed for restoration integrity, secondary caries, periodontal status and pulp sensibility responses. The impact of various prognostic factors on 5\u2010year success was analysed. Outcome measures at 5\u2010year were compared with 1\u2010year outcomes. Statistical tests included the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test, chi\u2010squared test, Fisher's exact test, McNemar's test, intention\u2010to\u2010treat analysis and binary logistic regression, with significance set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 5\u2009years, 59 of 88 participants (CP\u201428, PP\u201431) were available for follow\u2010up. The overall success was 83.05%, with no significant difference between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.494, RR\u2009=\u20091.10, 95% CI\u2009=\u20090.88\u20131.40). While both groups showed comparable evidence of HTB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.581, RR\u2009=\u20091.06, 95% CI\u2009=\u20090.91\u20131.23), PCO was significantly more evident in the CP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003, RR\u2009=\u20090.22, 95% CI\u2009=\u20090.07\u20130.70). The PP group elicited significantly more sensibility responses to cold test (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015, RR\u2009=\u20092.35, 95% CI\u2009=\u20091.09\u20137.43). Secondary caries was a significant prognostic factor influencing overall success at 5\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No significant differences in success, HTB, or PCO were observed between the 1 and 5\u2009years outcomes in either group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CP and PP demonstrated comparable success at 5\u2009years. PP may be preferred given its conservative approach, reduced risk of PCO, and more reliable pulp sensibility reoptimizing responses. Adequate restorative seal is crucial for long\u2010term success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT04397315\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70028","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T04:15:12Z","timestamp":1756872912000},"page":"1835-1848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome Following Complete and Partial Pulpotomy in Managing Cariously Exposed Mature Permanent Molars With Symptomatic Irreversible Pulpitis: A 5\u2010Year Follow\u2010Up of a Randomised Clinical Trial"],"prefix":"10.1111","volume":"58","author":[{"given":"Ankita","family":"Ramani","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences (PGIDS)  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Post Graduate Institute of Dental Sciences (PGIDS)  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2021.07.015"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2021.10.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1244-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-013-1003-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-012-0712-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.12.010"},{"key":"e_1_2_12_8_1","first-page":"317","article-title":"Outcome of Partial Pulpotomy Verses Full Pulpotomy Using Biodentine in Vital Mature Permanent Molar With Clinical Symptoms Indicative of Irreversible Pulpitis: A Randomized Clinical Trial","volume":"25","author":"Baranwal H. 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