{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:44:52Z","timestamp":1791549892405,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This randomised clinical trial compared the effect of wound lavage using chlorhexidine (CHX) versus sodium hypochlorite (NaOCl) on the outcome of partial pulpotomy (PP) in mature permanent molars with carious pulpal exposure and symptomatic irreversible pulpitis (SIP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In this double\u2010arm parallel\u2010group randomised clinical trial, 104 mandibular molars undergoing PP were randomised equally to either NaOCl lavage group (NL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952) or CHX lavage group (CL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200952). The pulpal wound after pulp amputation during PP was irrigated with 3% NaOCl in the NL and 2% CHX in the CL group. After haemostasis, ProRoot Mineral Trioxide Aggregate (ProRoot MTA) was used as a pulpotomy agent. Patients were evaluated for pain experience at every 24\u2009h for 7\u2009days, clinical success at 3, 6 and 12\u2009months, and radiographic success at 6 and 12\u2009months. Data were analysed using Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test to compare age, duration of haemostasis, pain score and analgesic consumption between groups and Chi\u2010square test\/Fisher's exact test to compare gender, the number of tooth surfaces involved by caries, hard tissue barrier, clinical and radiographic success, pain incidence and pulp sensibility responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010nine patients were assessed for clinical and radiographic success at 12\u2009months follow\u2010up. The NL group showed a higher success (91.8%) than the CL group (84%), albeit with no significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). No significant difference was observed between the groups in postoperative pain experience (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Significantly less time was required to achieve haemostasis in NL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and evidence of hard tissue barrier formation was significantly higher in the CL group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Comparable success was observed following the use of the two lavage agents during PP in managing cariously exposed adult teeth with SIP. CHX can serve as a suitable alternative to NaOCl as a pulpal wound lavage agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      identifier: NCT06240130\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70043","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T15:05:19Z","timestamp":1759244719000},"page":"80-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcome of Partial Pulpotomy in Mature Permanent Molars After Lavage With Chlorhexidine or Sodium Hypochlorite: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"59","author":[{"given":"Soumyashree","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigyasa","family":"Duhan","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Ramani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, PGIDS  Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"American Association of Endodontics (AAE).2020.\u201cGlossary of Endodontic Terms Tenth Edition.\u201dhttps:\/\/www.aae.org\/specialty\/clinical\u2010resources\/glossary\u2010endodontic\u2010terms\/."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04310-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.12.010"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201302168"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082408"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211046874"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2719-0"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13629"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2022.08.019"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23060"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.02.006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13866"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13080"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5853412"},{"key":"e_1_2_12_16_1","first-page":"29","article-title":"Partial Pulpotomy for Immature Permanent Teeth, Its Present and Future","volume":"24","author":"Fong C. 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