{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:59:48Z","timestamp":1772996388264,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to investigate the effects of copaiba oil\u2013resin on induced apical periodontitis in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A total of 24 male Wistar rats were divided equally into three groups (eight animals each): control (C), apical periodontitis (AP) and apical periodontitis with copaiba administration (AP\u2009+\u2009COP). The AP was induced by exposing the pulp chambers of the mandibular first molars to the oral environment. The openings were maintained for 28\u2009days to allow lesion development. The AP\u2009+\u2009COP group received systemic administration of 200\u2009mg\/kg of copaiba oil\u2013resin via intragastric gavage during the final 7\u2009days of the AP induction period. The rats were then euthanised, and their hemimandibles were subjected to histopathological analysis to assess tissue preservation, histochemical staining with picrosirius red to evaluate collagen content, and microcomputed tomography to assess lesion volume and bone quality parameters. Statistical analyses were performed using a one\u2010way ANOVA, followed by Tukey's post hoc test for parametric data and the Kruskal\u2013Wallis test for nonparametric data. The results are expressed as mean and standard error of the mean for parametric tests, and median and interquartile deviation for the nonparametric test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The findings showed that copaiba oil\u2013resin reduced lesion volume compared to the untreated group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0261), as well as reducing the space between the bone trabeculae found in the AP group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0063). Additionally, copaiba oil\u2013resin preserved the collagen fibres, which were more degraded in the untreated group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0009). Histopathological analysis showed that copaiba oil\u2013resin reduced tissue damage, preserving a significant area of alveolar bone surrounding the lesion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results indicate that copaiba oil resin has a promising adjunct therapeutic potential to reduce the bone loss caused by apical periodontitis and contribute to the maintenance of quality in the remaining bone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70063","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T14:07:22Z","timestamp":1763734042000},"page":"511-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Copaiba Oil\u2013Resin Reduces the Alveolar Bone Damage Triggered by Apical Periodontitis in Rats"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8119-746X","authenticated-orcid":false,"given":"Rayssa Mait\u00ea Farias","family":"Naz\u00e1rio","sequence":"first","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-2606","authenticated-orcid":false,"given":"Deborah Ribeiro","family":"Fraz\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-2723","authenticated-orcid":false,"given":"Leonardo Oliveira","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-2240","authenticated-orcid":false,"given":"Victoria Santos","family":"Chemelo","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8806-5500","authenticated-orcid":false,"given":"Jos\u00e9 M\u00e1rio","family":"Matos\u2010Sousa","sequence":"additional","affiliation":[{"name":"Laboratory of Functional and Structural Biology, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 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