{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:05:32Z","timestamp":1781780732043,"version":"3.54.5"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005322","name":"Recep Tayyip Erdogan \u00dcniversitesi","doi-asserted-by":"publisher","award":["TDH\u20102021\u20101266"],"award-info":[{"award-number":["TDH\u20102021\u20101266"]}],"id":[{"id":"10.13039\/501100005322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study was conducted to evaluate the effect of maintaining optimal serum vitamin D levels through supplementation on the healing rate and quality of newly formed bone at 3, 6, 9, and 12\u2009months in teeth with periapical lesions following endodontic treatment. Additionally, TNF\u2010\u03b1 levels were measured to investigate whether the potential healing effect was related to the anti\u2010inflammatory properties of vitamin D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      This study was designed as a parallel, triple\u2010blind, randomised controlled clinical trial registered at the Clinical Trials Registry. Seventy\u2010three male patients with mature mandibular molars presenting with periapical lesions and meeting the inclusion criteria were allocated into two groups: the vitamin D group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937) and the control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936). All patients received root canal treatment according to a standardised endodontic protocol. The vitamin D group received oral vitamin D supplements to raise serum 25(OH)D level to the optimal range (30\u201350\u2009ng\/mL), while the control group, with insufficient serum 25(OH)D levels (20\u201330\u2009ng\/mL), did not receive any supplementation. Periapical radiographs (pre\u2010op, 3, 6, 9, 12\u2009months), serum 25(OH)D (chemiluminescence), and TNF\u2010\u03b1 (ELISA) levels were assessed. The reduction in lesion area was calculated in mm2 and bone quality was assessed through fractal analysis. The data were statistically analysed using the Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      and Friedman tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Lesion area reduction was significantly greater in the vitamin D group versus the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, no significant difference was found between the vitamin D and control groups in terms of fractal analysis values and TNF\u2010\u03b1 levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A more rapid decrease in periapical lesion size was observed in individuals with serum vitamin D levels maintained within the optimal range (30\u201350\u2009ng\/mL). It is concluded that optimising vitamin D levels by supplementation, when appropriate, may be beneficial for the healing process of teeth with periapical lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: TCTR20221020006\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70066","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:40:31Z","timestamp":1763984431000},"page":"426-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of the Effect of Vitamin D Supplementation on Apical Lesion Healing Rate: Prospective, Randomised Clinical Trial"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-2935","authenticated-orcid":false,"given":"Edanur","family":"Mara\u015f","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Endodontics Recep Tayyip Erdo\u011fan University  Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Aricio\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Department of Endodontics, Istanbul Medeniyet University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7947-6874","authenticated-orcid":false,"given":"Hatice","family":"Beyazal Polat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Internal Medicine Recep Tayyip Erdo\u011fan University  Rize 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