{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:08:19Z","timestamp":1791274099011,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023915","name":"Faculty of Dentistry, Chulalongkorn University","doi-asserted-by":"publisher","award":["DRF67020"],"award-info":[{"award-number":["DRF67020"]}],"id":[{"id":"10.13039\/501100023915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the dental pulp response to different 38% silver diamine fluoride (SDF) products in Wistar rats with deep cavities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010four maxillary first molars from Wistar rats were randomly assigned to eight groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098 per group) for 7\u201328\u2009days treatments: Group 1\u2010 a locally produced 38% SDF (T\u2010SDF), Group 2\u2010Saforide (Toyo Seiyaku Kasei Co. Ltd., Japan), Group 3\u2010Topamine (Dentalife Australia Pty. Ltd., Thailand), and Group 4\u2010deionised water (DI) as control. After a deep cavity preparation, treatments were applied. Rats were euthanized at days 7 and 28 post\u2010treatment, and molars were subjected to histopathological examination to evaluate inflammation, soft tissue organisation, reactionary dentine formation and silver penetration depth. Data were analysed using the Kruskal\u2013Wallis; penetration depth was analysed using one\u2010way ANOVA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At day 7, all groups showed no to mild inflammation beneath the axial wall, with no significant differences in inflammation scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Normal odontoblastic organisation was observed in the T\u2010SDF and Saforide groups. Partial loss of soft tissue organisation occurred in 28.57% of the Topamine group and 16.66% of the DI group, though central pulp remained normal. Mean soft tissue organisation scores were 1.29 \u00b1\u20090.488 for Topamine and 1.17\u2009\u00b1\u20090.408 for DI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.203). Reactionary dentine formation was noted across most teeth, with no significant differences among groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.548). By day 28, no significant differences in inflammation or soft tissue organisation were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Reactionary dentine formation ranged from none to over four times the predentine thickness, with no significant group differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.932). The remaining dentine thickness of prepared cavities ranged from 71.70\u2013594.76\u2009\u03bcm. Silver precipitation was observed in all SDF\u2010treated specimens, absent in controls. Silver penetration into dentinal tubules toward the pulp showed no statistically significant differences among groups at both days 7 and 28 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.741 and 0.607, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When applied in deep cavities, SDF products elicited a dental pulp response comparable to that of the control, indicating their biocompatibility and safety for use in deep dentine carious lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70090","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:04:55Z","timestamp":1767153895000},"page":"669-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pulpal Response of Deep Cavities to Silver Diamine Fluoride Application in Wistar Rat Molars"],"prefix":"10.1111","volume":"59","author":[{"given":"Piyaporn","family":"Thamjareonsak","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wannakorn","family":"Sriarj","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tussapon","family":"Boonyarattanasoonthorn","sequence":"additional","affiliation":[{"name":"Chulalongkorn University Laboratory Animal Center Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio A.","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, College of Dentistry University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-4175","authenticated-orcid":false,"given":"Siriporn","family":"Songsiripradubboon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2017.24.5.11"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.56808\/2985-1130.2725"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.17796\/1053-4625-42.6.6"},{"key":"e_1_2_12_5_1","first-page":"22","article-title":"Effectiveness of Silver Diamine Fluoride in Caries Prevention and Arrest: A Systematic Literature Review","volume":"65","author":"Contreras V.","year":"2017","journal-title":"General Dentistry"},{"key":"e_1_2_12_6_1","first-page":"466","article-title":"Silver Diamine Fluoride Treatment Considerations in Children's Caries Management","volume":"38","author":"Crystal Y. 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