{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:39:23Z","timestamp":1788961163946,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare post\u2010operative pain following root canal treatment (RCT) in HIV\u2010positive patients receiving highly active antiretroviral therapy (HAART) and HIV\u2010negative patients and to assess the influence of systemic condition on endodontic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      This investigation was designed as a prospective observational cohort study, following the PROBE 2023 guidance. A total of 60 patients (30 HIV\u2010positive under HAART for at least three years with undetectable viral load, and 30 HIV\u2010negative) with pulp necrosis and asymptomatic apical periodontitis were included. All teeth were treated in a single visit by an endodontic specialist using standardised chemo\u2010mechanical preparation with reciprocating instruments, irrigation with 2.5% sodium hypochlorite and 17% EDTA, and single\u2010cone obturation with AH Plus sealer. Patients without preoperative pain (VAS\u2009=\u20090) were included. Post\u2010operative pain was assessed using a VAS, 0\u201310 at 6, 12, 24, 48 and 72\u2009h and 7\u2009days post\u2010treatment. Statistical analysis was performed using the chi\u2010square test, Kolmogorov\u2013Smirnov test, and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test (95% confidence level).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant differences were found between groups regarding sex, age or tooth location (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Both groups reported postoperative pain in the first 24\u2009h, with no significant differences (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). At 48\u2009h, however, all HIV\u2010positive patients reported complete pain relief, whereas the HIV\u2010negative group still presented residual pain, showing a statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). At 72\u2009h and 7\u2009days, both groups reported no pain (VAS\u2009=\u20090). Overall, postoperative pain prevalence exceeded 45% in the first 24\u2009h, regardless of systemic condition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postoperative pain patterns were similar in HIV\u2010positive patients under HAART and HIV\u2010negative individuals, except for earlier pain resolution in the HIV\u2010positive group at 48\u2009h. These findings suggest that the systemic condition does not negatively affect the short\u2010term management of endodontic pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70110","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:54:13Z","timestamp":1770267253000},"page":"788-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postoperative Pain After Endodontic Treatment in\n                    <scp>HIV<\/scp>\n                    \u2010Positive Patients Under\n                    <scp>HAART<\/scp>\n                    : A Prospective Observational Cohort Study"],"prefix":"10.1111","volume":"59","author":[{"given":"Marcos Felipe Iparraguirre","family":"Nu\u00f1overo","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio Hungaro","family":"Duarte","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Reis Azevedo","family":"Alanis","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Cavalini","family":"Cavenago","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1 (UFPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulisses Xavier","family":"da Silva Neto","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-5396","authenticated-orcid":false,"given":"Everdan","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 (PUCPR)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1744806920927276"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"555","article-title":"Comparative Evaluation of the Effectiveness of Intracanal and Intraoral Cryotherapy on Postendodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Clinical Trial","volume":"26","author":"Ajeesh K.","year":"2023","journal-title":"Journal of Conservative Dentistry and Endodontics"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"155","article-title":"Comparison of the Success of Root Canal Therapy in HIV\/AIDS Patients and Non\u2010Infected Controls","volume":"56","author":"Alley B. 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