{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:06:56Z","timestamp":1780387616246,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022\u2010MS\u2010238"],"award-info":[{"award-number":["2022\u2010MS\u2010238"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effects of locally applied liquid\/gel mixed\u2010phase concentrated growth factor (lgpCGF) on periodontal and pulpal healing following delayed replantation of avulsed immature permanent teeth and explore the potential of lgpCGF in mitigating root resorption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A delayed replantation model in immature permanent teeth was established using eight healthy beagle dogs, with two additional dogs serving as normal controls. From each experimental animal, two mandibular canine teeth (33 and 43) were extracted and left dry for 60\u2009min to simulate delayed replantation. Tooth 43 received freshly prepared lgpCGF in the alveolar socket before replantation (lgpCGF group), while tooth 33 underwent conventional replantation (CR group). Each group initially contained 8 teeth (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098); one tooth in the CR group was excluded due to extraction\u2010related damage. Periapical radiographs were obtained immediately after replantation and again at 4\u2009weeks postoperatively, and analysed utilising ImageJ software. Micro\u2010computed tomography (micro\u2010CT) combined with CT\u2010Analyser, ImageJ, and Geomagic Wrap was performed for quantitative assessment of root resorption. Surface resorption (SRR) and\/or inflammatory root resorption (IRR) were grouped together and quantified collectively as the proportion of total root surface area affected. Replacement resorption (RRR) was evaluated by measuring the arc length of resorbed areas relative to the total root perimeter on transverse sections. Histological evaluation of periodontal and pulpal tissues was conducted on haematoxylin and eosin\u2010stained sections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the CR group, the lgpCGF group exhibited improved clinical signs with fewer high\u2010pitched percussion responses and greater tooth stability. Radiographic and micro\u2010CT analyses revealed that the lgpCGF group had a significantly longer root length and smaller apical foramen diameter compared to the CR group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additionally, the lgpCGF group showed greater root area and reduced root resorption compared to the CR group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Histological observations further showed enhanced periodontal regeneration and pulpal tissue organisation in lgpCGF\u2010treated teeth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Local application of lgpCGF to the alveolar socket during delayed replantation of immature permanent teeth effectively reduced root resorption and enhanced periodontal and pulpal healing. These findings support lgpCGF's potential as a regenerative therapeutic strategy to improve the prognosis of delayed tooth replantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70122","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:07:49Z","timestamp":1772971669000},"page":"1430-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liquid\/Gel Mixed\u2010Phase Concentrated Growth Factors Enhance Periodontal and Pulpal Healing in Delayed Replantation of Immature Permanent Teeth: A Study in Beagle Dogs"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1312-2755","authenticated-orcid":false,"given":"Tiange","family":"Li","sequence":"first","affiliation":[{"name":"Department of Paediatric Dentistry, School and Hospital of Stomatology China Medical University  Shenyang China"},{"name":"Liaoning Province Key Laboratory of 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