{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:58:46Z","timestamp":1789016326019,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2023\/00536\u20100"],"award-info":[{"award-number":["#2023\/00536\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2023\/01400\u20104"],"award-info":[{"award-number":["#2023\/01400\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2022\/04868\u20104"],"award-info":[{"award-number":["#2022\/04868\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigates the relationship between maternal apical periodontitis (AP) and neonatal health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>Twenty\u2010four Wistar rats were assigned to three groups: control (CN), one induced apical periodontitis (AP1), and four induced apical periodontitis (AP4). Apical periodontitis was induced for all experimental groups. After 30\u2009days, the rats were mated and sacrificed on the 21st day of gestation. Placental weight, maternal glycemia, insulinemia, insulin resistance, and placental protein levels were analysed. Neonates were evaluated for their number, weight, capillary glycemia, and liver tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) content.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that no significant differences were observed in maternal glycemia. However, insulinemia and homeostatic model assessment for insulin resistance were higher in the AP groups compared with CN and were more pronounced in AP4 than AP1. Placental weight and placental labyrinth area were reduced exclusively in the AP4 group, while the number of fetuses per rat did not differ among groups. The AP4 group exhibited increased placental TNF\u2010\u03b1 gene expression and protein content compared with CN and AP1. In addition, placental caspase\u20103 expression was increased in the AP4 group, with no significant differences in nuclear factor\u2010kappaB (p50 and p65) phosphorylation status among groups. Foetal analyses demonstrated a reduction in naso\u2010anal length in fetuses from the AP4 group, lower capillary glycemia in fetuses from AP rats compared with CN, and increased TNF\u2010\u03b1 content in foetal liver tissue from AP groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, most alterations were more pronounced with an increasing number of maternal teeth affected by AP, emphasizing the importance of maternal oral health in preventing placental dysfunction and adverse fetal developmental outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70155","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T10:45:31Z","timestamp":1775817931000},"page":"1858-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Foetal Development and Placental Health in Response to Apical Periodontitis Induced in Pregnant Wistar Rats"],"prefix":"10.1111","volume":"59","author":[{"given":"Ana Carla Thalez Ywabuchi","family":"Nobumoto","sequence":"first","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-4071","authenticated-orcid":false,"given":"Thais Ver\u00f4nica Saori","family":"Tsosura","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sara","family":"de Lima Coutinho Mattera","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Elvira","family":"Belardi","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Clara","family":"Cachoni","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Graduate Program in Dental Science S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-275X","authenticated-orcid":false,"given":"Rodrigo Martins","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"de Oliveira Alves","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Umbelino","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane Stephanie Mendon\u00e7a","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0805-1120","authenticated-orcid":false,"given":"Sandra Helena Penha","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-0583","authenticated-orcid":false,"given":"Edilson","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-7846","authenticated-orcid":false,"given":"Luciano Tavares Angelo","family":"Cintra","sequence":"additional","affiliation":[{"name":"Graduate Program in Dental Science S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Department of Preventive and Restorative Dentistry S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris Hissako","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"},{"name":"Graduate Program in Dental Science S\u00e3o Paulo State University (UNESP), School of Dentistry  Ara\u00e7atuba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010015\u20100762\u2010z"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2022.10813"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed9010013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.12.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/1519\u20106984.221405"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12486"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.110"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150916153"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.782"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.02.042"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.1.8536607"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40496\u2010024\u201000371\u20106"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12295"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.04.029"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12817"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5320156"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2017.05.021"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12177"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509092"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26252"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-09071-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010021\u201000610\u2010y"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010022\u201002632\u20106"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo\u2010reports\/kve248"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594\u2010019\u20100188\u2010z"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400476"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.02.15.528712"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006514\u2010w"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MIR0817\u2010346RRR"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.1340016"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP090442"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0103\u201064402007000400001"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc\u20102020\u2010001728"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052473"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13474"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010025\u201007337\u20101"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/cmr.00103\u201018"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13096"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12122908"},{"key":"e_1_2_12_42_1","volume-title":"Placental Insufficiency. In: StatPearls","author":"Wardinger J. E.","year":"2022"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.149"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01199.2008.\u2010We"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5263"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010021\u201008907\u20109"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2014.00290"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70155","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.70155","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:25:19Z","timestamp":1786512319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.70155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/iej.70155"],"URL":"https:\/\/doi.org\/10.1111\/iej.70155","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}