{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:36:25Z","timestamp":1787740585257,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19\u2010DE\u201022516"],"award-info":[{"award-number":["U19\u2010DE\u201022516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19\u2010DE\u201028717"],"award-info":[{"award-number":["U19\u2010DE\u201028717"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to identify dentist, patient, and pre\u2010treatment clinical characteristics associated with local anaesthesia failure during non\u2010surgical endodontic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Data were collected from the National Dental Practice\u2010Based Research Network study entitled \u201cPredicting Outcomes of Root Canal Treatment (PREDICT)\u201d, which included 1723 patients. Local anaesthesia failure during treatment was defined as patient\u2010reported pain of 3 or greater on a 0\u2010to\u201010\u2010point scale. Pre\u2010treatment factors included patient demographics, psychosocial constructs, and pre\u2010treatment clinical findings (e.g., abnormal sensitivity to cold, biting, percussion, palpation). Characteristics with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.1 (after adjustment for clustering with generalized estimating equations) were entered into a model to identify independent associations with failed anaesthesia, and odds ratios were calculated to measure the strength of these associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 16% of patients reported intra\u2010operative local anaesthesia failure. Failure was associated with patient age\u2009&lt;\u200955\u2009years (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05), dental treatment fear (\u201csome\u201d to \u201cextremely afraid\u201d) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), mandibular teeth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and greater numbers of abnormal pre\u2010treatment diagnostic findings (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Protective factors included having treatment done by an endodontist (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), and the patient being non\u2010Hispanic White (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Comparisons of local anaesthetic techniques by dentist type (general dentist vs. endodontist) showed statistically significant differences in the bivariate analysis, but none remained significant after adjustment for clustering of patients within dentist.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Local anaesthesia failed in 16% of cases. Pre\u2010treatment fear was the only significant psychosocial predictor of intra\u2010operative pain. Failure was more likely in mandibular teeth and when multiple abnormal tests were present pre\u2010operatively (e.g., cold sensitivity, percussion tenderness). Younger patients reported more pain, and endodontists had lower pain rates than general dentists.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70171","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:27:21Z","timestamp":1779103641000},"page":"1817-1830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Psychosocial Predisposing Factors Associated With Anaesthesia Failure During Non\u2010Surgical Root Canal Treatment: A National Dental Practice\u2010Based Research Network Study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5271-0969","authenticated-orcid":false,"given":"Linda J.","family":"Liu","sequence":"first","affiliation":[{"name":"Division of Endodontics, Department of Restorative Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-0828","authenticated-orcid":false,"given":"Ronald","family":"Ordinola\u2010Zapata","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Restorative Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9982-3219","authenticated-orcid":false,"given":"W. Craig","family":"Noblett","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Restorative Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-6491","authenticated-orcid":false,"given":"Ellen","family":"Funkhouser","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-2390","authenticated-orcid":false,"given":"Alan S.","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Department of Restorative Sciences, School of Dentistry University of Minnesota  Minneapolis Minnesota USA"},{"name":"Specialty Practices  West Roseville Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1757-9592","authenticated-orcid":false,"given":"Donald R.","family":"Nixdorf","sequence":"additional","affiliation":[{"name":"Division of TMD and Orofacial Pain University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-6884","authenticated-orcid":false,"given":"Ernest W. N.","family":"Lam","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2327-9115","authenticated-orcid":false,"given":"Rahma","family":"Mungia","sequence":"additional","affiliation":[{"name":"Department of Periodontics, School of Dentistry The University of Texas Health San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-625X","authenticated-orcid":false,"given":"Gregg H.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Clinical and Community Sciences, School of Dentistry University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The National Dental Practice\u2010Based Research Network Collaborative Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258268"},{"key":"e_1_2_13_3_1","unstructured":"American Dental Association Health Policy Institute.2022.\u201cDentists Who Participate in Medicaid: Who They Are Where They Practice. 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