{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:33:22Z","timestamp":1786512802492,"version":"build-2736575974"},"reference-count":87,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970926"],"award-info":[{"award-number":["81970926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01709"],"award-info":[{"award-number":["2023J01709"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2022QNA073"],"award-info":[{"award-number":["2022QNA073"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Aim<\/jats:title>\n This study investigated the impact of apical periodontitis (AP) on ulcerative colitis (UC) progression and elucidated the roles of intestinal barrier dysfunction and neutrophil extracellular traps (NETs) in a mouse model, providing new evidence and perspectives for oral\u2010systemic diseases.<\/jats:p>\n <\/jats:sec>\n \n Methodology<\/jats:title>\n \n Thirty\u2010two male ICR mice were randomized into four groups (\n n<\/jats:italic>\n \u2009=\u20098 per group): Ctrl, AP, UC and AP\u2009+\u2009UC. AP was induced by lipopolysaccharide application to the bilateral maxillary first and second molars. UC was established via dextran sulphate sodium administration. Disease activity index (DAI), colon length and histopathology were assessed. Serum levels of C\u2010reactive protein (CRP), interleukin (IL)\u20106, IL\u201010, IL\u20101\u03b2, immunoglobulin G (IgG) and NETs were measured by ELISA. Intestinal tight junction proteins (ZO\u20101 and Claudin) and NETs were analysed via immunofluorescence. Gut microbiota composition was evaluated by 16S rRNA sequencing.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n AP\u2009+\u2009UC mice exhibited significantly higher DAI scores (\n p<\/jats:italic>\n \u2009<\u20090.01 vs. UC), shortened colon length (\n p<\/jats:italic>\n \u2009<\u20090.05 vs. UC) and exacerbated histopathological damage (\n p<\/jats:italic>\n \u2009<\u20090.01 vs. UC). Serum CRP, IL\u20101\u03b2 and IL\u20106 levels were elevated in AP\u2009+\u2009UC mice (\n p<\/jats:italic>\n \u2009<\u20090.05 vs. UC). Levels of NETs increased significantly in AP\u2009+\u2009UC serum (\n p<\/jats:italic>\n \u2009<\u20090.05 vs. UC) and colonic tissue. AP and AP\u2009+\u2009UC groups showed reduced goblet cell areas (\n p<\/jats:italic>\n \u2009<\u20090.01 AP vs. Ctrl,\n p<\/jats:italic>\n \u2009<\u20090.01 AP\u2009+\u2009UC vs. UC) and diminished tight junction protein expression. Gut microbiota analysis revealed increased alpha diversity and altered genus\u2010level composition in AP\u2009+\u2009UC mice, with significant correlations between specific bacteria and NETs levels\/goblet cell areas.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n AP may exacerbate UC severity through intestinal barrier impairment and systemic NETs elevation, accompanied by gut microbiota dysbiosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/iej.70182","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:21:06Z","timestamp":1779358866000},"page":"1902-1916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apical Periodontitis May Exacerbate Ulcerative Colitis via Neutrophil Extracellular Trap\u2010Mediated Systemic Inflammation and Intestinal Barrier Disruption in Mice"],"prefix":"10.1111","volume":"59","author":[{"given":"Yu","family":"Zeng","sequence":"first","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peining","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachen","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihan","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Luo","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Stomatology Fujian Medical University Union Hospital Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3189-9915","authenticated-orcid":false,"given":"Guowu","family":"Gan","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatology Key Lab of Fujian College and University School and Hospital of Stomatology, Fujian Medical University Fuzhou China"},{"name":"Institute of Stomatology & Research Center of Dental and Craniofacial Implants School and Hospital of Stomatology, Fujian Medical University Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13902"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2021.673552"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz129"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000460"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.12.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010018\u20100470\u2010z"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-021-00636-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2025.01.021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1020126"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.08.019"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09646"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14119"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15197"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2019.07.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12468"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-025-06383-5"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-333729"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10214886"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.07.027"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.71"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2023.11.003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.09.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1639178"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153179"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2024.02.026"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.07.007"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2019.52824"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10209"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20221751"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.048"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdmed.2025.1553914"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051504"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2FO03263E"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.22-0205"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02746-6"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.05.026"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/jimr\/8039031"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03191-6"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-024-01014-8"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14214"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00050-12"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.4103\/ejd.ejd_84_17"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366954"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425919889392"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00635"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13477"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13481"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab289"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-023-01000-9"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12698"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0992-y"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2019-0699"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13472"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-024-00746-6"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.11.004"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13444"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.24135"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izz128"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211049781"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.028"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03919-3"},{"key":"e_1_2_11_66_1","first-page":"211","article-title":"Prevalence of Periapical Abscesses in Patients With Rheumatoid Arthritis. A Cross Sectional Study","volume":"34","author":"Rotstein I.","year":"2021","journal-title":"American Journal of Dentistry"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2222-z"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.09.008"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13789"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-025-06246-z"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2016.11.012"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.5937\/SJECR14\u20104340"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-017-0401-6"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1144976"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14125"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5120118"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515609097"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12628"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.044"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3353"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5263"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2021.01.005"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.114002"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1646-6"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.856118"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-025-06161-3"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.70182","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T05:25:47Z","timestamp":1786512347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.70182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/iej.70182"],"URL":"https:\/\/doi.org\/10.1111\/iej.70182","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"assertion":[{"value":"2025-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}