{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:06:08Z","timestamp":1789171568691,"version":"build-2803163510"},"reference-count":135,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The transition from reversible to irreversible pulpitis remains inadequately defined at the molecular level. Current classifications rely largely on clinical symptoms rather than objective biological determinants, limiting diagnostic precision and therapeutic decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To integrate current experimental and translational evidence positioning inflammasomes as central molecular decision\u2010making platforms in pulpal inflammation, and to propose a biologically grounded model in which inflammasome activation and supramolecular assembly define the threshold separating adaptive, reversible inflammation from irreversible pulpal damage, with direct clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A structured narrative review was conducted following a comprehensive literature search of PubMed\/MEDLINE, Scopus, and Web of Science from inception to December 2025. Evidence derived from in\u00a0vitro systems, in\u00a0vivo animal models, and analyses of human inflamed pulpal tissues was synthesised to characterise inflammasome sensors, adaptor and effector components, regulatory checkpoints, downstream inflammatory outputs, and their relevance to pulpal disease progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dental pulp cells express functional inflammasome sensors, including NLRP3, AIM2, and NLRP6, which respond to inflammatory, metabolic, and damage\u2010associated signals. Inflammasome activation follows a stepwise process of transcriptional priming and threshold\u2010dependent assembly. While NF\u2010\u03baB\u2013 and type I interferon\u2013mediated priming is adaptive and potentially reversible, ASC speck formation represents a molecular commitment point leading to caspase\u20101 activation, gasdermin D cleavage, IL\u20101\u03b2\/IL\u201018 maturation, and pyroptotic cell death. Mitochondrial dysfunction, cytosolic mtDNA release, sustained ion fluxes, P2X7 signalling, and loss of endogenous inhibitory regulators further amplify inflammasome activity, promoting self\u2010sustaining inflammatory circuits and progressive tissue breakdown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pulpal inflammation should be understood not as a linear increase in microbial burden, but as a biological transition driven by inflammasome checkpoint failure. Irreversible ASC speck formation functions as a commitment switch that sustains caspase\u20101 activation, gasdermin D\u2013mediated pyroptosis, and self\u2010amplifying IL\u20101\u03b2\/IL\u201018 signalling. Within the confined pulp environment, this feed\u2010forward inflammatory circuitry promotes neurovascular dysregulation and severe pain, ultimately becoming uncoupled from the initiating insult and incompatible with tissue recovery. Recognising Inflammasome activation (ASC speck formation) as a point of no return may refine diagnostic paradigms and help redefine the biological limits of vital pulp therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70185","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:50:38Z","timestamp":1779781838000},"page":"1986-2027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redefining the Evolution of Pulpal Pathology: Inflammasomes as Central Integrative Hubs and Biological Switches Governing the Transition From Reversible to Irreversible Pulpal Inflammation Beyond Symptom\u2010Based Classification"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-6789","authenticated-orcid":false,"given":"N\u00e9stor","family":"R\u00edos\u2010Osorio","sequence":"first","affiliation":[{"name":"Department of Endodontics, School of Dentistry CES University  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-2635","authenticated-orcid":false,"given":"James L.","family":"Gutmann","sequence":"additional","affiliation":[{"name":"Department of Endodontics, College of Dentistry Texas A&amp;M University  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-2306","authenticated-orcid":false,"given":"Tatiana M.","family":"Botero","sequence":"additional","affiliation":[{"name":"Department of Cariology, Restorative Sciences and Endodontics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-8850","authenticated-orcid":false,"given":"Nessrin","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8373","authenticated-orcid":false,"given":"Rafael","family":"Fern\u00e1ndez\u2010Grisales","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry CES University  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-4925","authenticated-orcid":false,"given":"Mario","family":"Guerrero\u2010Torres","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Universidad Santo Tomas  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8243","authenticated-orcid":false,"given":"Emmanuel J. N. L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Program in Translational Biomedicine (BIOTRANS) Grande Rio University (UNIGRANRIO)  Rio de Janeiro Brazil"},{"name":"Department of Endodontics Fluminense Federal University  Rio de Janeiro Brazil"},{"name":"Department of Endodontics Rio de Janeiro University (UERJ)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0407-9847","authenticated-orcid":false,"given":"Javier","family":"Caviedes\u2010Bucheli","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Odontol\u00f3gicas Pontificia Universidad Javeriana  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.11.011"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13855"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13483"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27021098"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/23337931.2017.1409075"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-022-04486-1"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.06.008"},{"issue":"7","key":"e_1_2_19_9_1","article-title":"Hypoxia\u2010Inducible Factor 1\u2010Alpha (HIF\u20101\u03b1): An Essential Regulator in Cellular Metabolic Control","volume":"16","author":"Basheeruddin M.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201516"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202115415"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3795-08.2008"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.879021"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414530200"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2023-0230"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01224-x"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.03.010"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2012.02.030"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2015.10.008"},{"key":"e_1_2_19_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2023.11.009"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e41730"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01533364"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.720147"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3144"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511413284"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2016.69"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.017897"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2020.05.006"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-020-00370-3"},{"key":"e_1_2_19_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1235-0"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2006.09.013"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612"},{"key":"e_1_2_19_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00289"},{"key":"e_1_2_19_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.06.019"},{"key":"e_1_2_19_36_1","first-page":"200","article-title":"Docking Study of Ligands Targeting NLRP3 Inflammatory Pathway for Endodontic Diseases","volume":"7","author":"Erdag E.","year":"2023","journal-title":"Chemical Methodologies"},{"key":"e_1_2_19_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.005"},{"key":"e_1_2_19_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01426"},{"key":"e_1_2_19_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.67"},{"key":"e_1_2_19_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07710"},{"key":"e_1_2_19_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050762"},{"key":"e_1_2_19_42_1","doi-asserted-by":"crossref","unstructured":"Gombault A. L.Baron andI.Couillin.2013.ATP Release and Purinergic Signalling in NLRP3 Inflammasome Activation.","DOI":"10.3389\/fimmu.2012.00414"},{"key":"e_1_2_19_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S507198"},{"key":"e_1_2_19_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13926"},{"key":"e_1_2_19_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.02.006"},{"key":"e_1_2_19_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200312"},{"key":"e_1_2_19_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep40681"},{"key":"e_1_2_19_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100030501"},{"key":"e_1_2_19_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1214289"},{"key":"e_1_2_19_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-12-9"},{"key":"e_1_2_19_51_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0312OC"},{"key":"e_1_2_19_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0697-z"},{"key":"e_1_2_19_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9963-5"},{"key":"e_1_2_19_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00908-X"},{"key":"e_1_2_19_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13831"},{"key":"e_1_2_19_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-015-2118-7"},{"key":"e_1_2_19_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13814"},{"key":"e_1_2_19_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3757"},{"key":"e_1_2_19_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2007.01.001"},{"key":"e_1_2_19_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.09.002"},{"key":"e_1_2_19_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240248"},{"key":"e_1_2_19_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxx018"},{"key":"e_1_2_19_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26144129"},{"key":"e_1_2_19_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04885-8"},{"key":"e_1_2_19_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11588"},{"key":"e_1_2_19_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1361-8"},{"key":"e_1_2_19_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1284868"},{"key":"e_1_2_19_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2018.04.003"},{"key":"e_1_2_19_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.07.012"},{"key":"e_1_2_19_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_2_19_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202505666"},{"key":"e_1_2_19_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13091"},{"key":"e_1_2_19_73_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.122.000629"},{"issue":"2","key":"e_1_2_19_74_1","first-page":"209","article-title":"Up\u2010Regulation of TLR2 and TLR4 in High Mobility Group Box1\u2010Stimulated Macrophages in Pulpitis Patients","volume":"20","author":"Mahmoudi J.","year":"2017","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_19_75_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191430"},{"key":"e_1_2_19_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_2_19_77_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040620"},{"key":"e_1_2_19_78_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109"},{"key":"e_1_2_19_79_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0907629"},{"key":"e_1_2_19_80_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7046.1"},{"key":"e_1_2_19_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00763"},{"key":"e_1_2_19_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14078"},{"key":"e_1_2_19_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/jispcd.jispcd_31_25"},{"key":"e_1_2_19_84_1","article-title":"The PRISMA2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page M. J.","year":"2021","journal-title":"BMJ (Clinical Research Ed.)"},{"key":"e_1_2_19_85_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00862-13"},{"key":"e_1_2_19_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01404-2"},{"key":"e_1_2_19_87_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201202500118"},{"key":"e_1_2_19_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1474466"},{"key":"e_1_2_19_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.595301"},{"key":"e_1_2_19_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.104761"},{"key":"e_1_2_19_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.02.006"},{"key":"e_1_2_19_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167289"},{"key":"e_1_2_19_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5405.1183"},{"key":"e_1_2_19_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545772"},{"key":"e_1_2_19_95_1","first-page":"884","article-title":"Expression of NLRP3 and mTORC1 Post\u2010LPS Induction in Pyroptosis of Nerve Cells in Dental Pulp Tissue","volume":"7","author":"Sampoerno G.","year":"2025","journal-title":"J Med Pharm Chem Res"},{"key":"e_1_2_19_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11010149"},{"key":"e_1_2_19_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"e_1_2_19_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_19_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13683"},{"key":"e_1_2_19_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.02.011"},{"key":"e_1_2_19_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-018-0024-z"},{"key":"e_1_2_19_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01016"},{"key":"e_1_2_19_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.5948"},{"key":"e_1_2_19_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.10.020"},{"key":"e_1_2_19_105_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555218786210"},{"key":"e_1_2_19_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"e_1_2_19_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13469"},{"key":"e_1_2_19_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.2.151"},{"key":"e_1_2_19_109_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4804"},{"key":"e_1_2_19_110_1","volume-title":"Translational Pain Research: From Mouse to Man","author":"Toulme E.","year":"2010"},{"key":"e_1_2_19_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12541"},{"key":"e_1_2_19_112_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2040188"},{"key":"e_1_2_19_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13413"},{"key":"e_1_2_19_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04936-w"},{"key":"e_1_2_19_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13442"},{"key":"e_1_2_19_116_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01487"},{"key":"e_1_2_19_117_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20209"},{"key":"e_1_2_19_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3105cm1"},{"key":"e_1_2_19_119_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S516502"},{"key":"e_1_2_19_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80402-1"},{"key":"e_1_2_19_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.07.016"},{"key":"e_1_2_19_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.70084"},{"key":"e_1_2_19_123_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076126"},{"key":"e_1_2_19_124_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.314845"},{"key":"e_1_2_19_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12339"},{"issue":"1","key":"e_1_2_19_126_1","first-page":"12","article-title":"NLRP1 and NLRC4 Inflammasomes Are Not Responsible for the Induction of Inflammation in Pulp Tissues From Carious Teeth","volume":"22","author":"Yaghooti Khorasani M. M.","year":"2019","journal-title":"Journal of Conservative Dentistry: JCD"},{"key":"e_1_2_19_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2014.06.015"},{"key":"e_1_2_19_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-025-00369-5"},{"key":"e_1_2_19_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13100836"},{"key":"e_1_2_19_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13400"},{"key":"e_1_2_19_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.009"},{"key":"e_1_2_19_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021\u20109150(01)00672\u20104"},{"key":"e_1_2_19_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13258"},{"key":"e_1_2_19_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00770-z"},{"key":"e_1_2_19_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104794"},{"key":"e_1_2_19_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2024.119823"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.70185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:12:16Z","timestamp":1789168336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.70185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":135,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/iej.70185"],"URL":"https:\/\/doi.org\/10.1111\/iej.70185","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}