{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:06:13Z","timestamp":1789171573832,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To outline the biological and electrochemical principles supporting impedance\u2010guided localisation of pulp chambers and canal orifices in calcified root canal systems, and to present an accessory concept relating to impedance patterns at the coronal dentine\u2013gutta\u2010percha interface, potentially serving as a surrogate marker of fluid leakage associated with deficient non\u2010conductive root fillings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Calcific metamorphosis produces structural alterations that complicate localisation of pulp chambers and canal orifices. Adjunctive modalities such as CBCT, guided endodontics, microscopic magnification and ultrasonic troughing provide geometric information but lack real\u2010time biological feedback. Electrical impedance behaviour differs significantly between sclerotic dentine and residual conductive pathways and offers a biological cue during access. The impedance\u2010guided localisation concept applies these principles through a structured, conservative workflow. In addition, impedance patterns observed at coronal dentine\u2013gutta\u2010percha interfaces will, in theory, reflect electrochemical variations associated with potential fluid leakage and the reduced effectiveness of existing non\u2010conductive root fillings to provide a fluid\u2010tight seal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Impedance\u2010guided localisation may provide a biologically grounded adjunct to visual and geometric strategies for locating pulp chambers and canal orifices when managing calcified root canal systems during root canal treatment. The interface\u2010related impedance concept serves as an optional scientific extension, derived from established electrochemical principles, that may offer insight into potential fluid leakage or reduced sealing effectiveness associated with non\u2010conductive root canal fillings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Impedance\u2010guided pulp chamber and canal orifice localisation provides real\u2010time biological feedback that reduces the risk of iatrogenic perforations and enhances conservative dentine management, particularly for inexperienced clinicians with potential relevance for preclinical training and early clinical education. The accessory interface\u2010related impedance concept may offer surrogate insight into potential leakage or reduced sealing effectiveness of root fillings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70187","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:39:48Z","timestamp":1780893588000},"page":"2255-2266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impedance\u2010Guided Localisation of Pulp Chambers and Canal Orifices in Calcified Root Canal Systems: Biological Foundations and Conceptual Application"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-5172","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Nekoofar","sequence":"first","affiliation":[{"name":"Department of Endodontics, School of Dentistry Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Tissue Engineering, School of Advanced Technologies in Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-7467","authenticated-orcid":false,"given":"Paul M. 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