{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:06:04Z","timestamp":1789171564382,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13269\u20101"],"award-info":[{"award-number":["2020\/13269\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effects of predictable and unpredictable chronic stress on the development and severity of periapical lesions in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two male Wistar rats were randomly allocated into four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098 each): control, apical periodontitis without stress, apical periodontitis with predictable stress, and apical periodontitis with unpredictable stress. Emotional stress protocols were applied for 42\u2009days, and apical periodontitis was induced on day 21 by pulp exposure. Stress induction was confirmed through behavioural evaluation using the open field and Y\u2010maze tests. The severity of periapical lesions was assessed by microcomputed tomography and histological analysis. Data were analysed using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, Mann\u2013Whitney, one\u2010way ANOVA, or Kruskal\u2013Wallis tests (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Behavioural tests confirmed successful stress induction, with both stressed groups demonstrating reduced exploratory activity compared to non\u2010stressed animals. Animals exposed to unpredictable stress developed significantly larger periapical lesions and exhibited higher inflammatory infiltrate scores than those subjected to predictable stress or no stress (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Microcomputed tomography findings corroborated the histological results, confirming the greater severity of apical periodontitis in the unpredictable stress group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unpredictable chronic stress significantly exacerbated the development and severity of periapical lesions, suggesting that stress predictability may act as a modulatory factor in apical periodontitis progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70203","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:17:32Z","timestamp":1781929052000},"page":"2201-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Stress Predictability Modulates the Severity of Apical Periodontitis Induced in Wistar Rats"],"prefix":"10.1111","volume":"59","author":[{"given":"Giovanna Bignoto","family":"Minhoto","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo G.","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayana D.","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina O.","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Endodontics Juiz de Fora Federal University (UFJF)  Governador Valadares Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina F.","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila G. C.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8243","authenticated-orcid":false,"given":"Emmanuel J. N. L.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Endodontics Rio de Janeiro State University (UERJ)  Rio de Janeiro Brazil"},{"name":"Department of Endodontics Grande Rio University (UNIGRANRIO)  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-6438","authenticated-orcid":false,"given":"Marcia C.","family":"Valera","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, Endodontic Division, S\u00e3o Paulo State University \u2013 UNESP Institute of Science and Technology  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3193725"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crneur.2021.100013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105996"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13857"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103728"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00347"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2015.09.022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.10.004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080183"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2025.106422"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010018\u20100167\u20109"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185129"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2632"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104590"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20108994\u20102_9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104693"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/EMM.2014.65"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.08.021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13515"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005\u20101041"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12507"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2019.05.017"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.14125"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149\u20107634(05)80194\u20100"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37192"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2025.101953"}],"container-title":["International Endodontic Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iej.70203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iej.70203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:58Z","timestamp":1789168318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iej.70203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/iej.70203"],"URL":"https:\/\/doi.org\/10.1111\/iej.70203","archive":["Portico"],"relation":{},"ISSN":["0143-2885","1365-2591"],"issn-type":[{"value":"0143-2885","type":"print"},{"value":"1365-2591","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"2026-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}