{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:44:00Z","timestamp":1792176240064,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004035","name":"Jordan University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assimilate data from individual randomised trials and perform a pooled analysis of short\u2010term outcomes of pulpotomy compared with root canal treatment (RCT) for teeth with symptomatic irreversible pulpitis (SIRP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomised trials were conducted in eight countries using a standardised clinical protocol and outcome measures. Inclusion criteria were a diagnosis of SIRP in a restorable tooth that could be adequately isolated. A block randomisation method was used. Short\u2010term outcomes were postoperative pain (assessed at baseline, day 3 and day 7), analgesic consumption and early failure, which was defined as the need for additional intervention within 4\u2009weeks of treatment. Data were analysed using R v4.3.1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 410 patients were randomised, with data available for 385 patients. A significant reduction in pain intensity was observed over time for each treatment group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Participants who received RCT were observed to have a significantly greater decrease in pain intensity between baseline and day 3, mean Numeric Rating Scale (NRS\u201011) of 1.7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0034) and from day 3 to day 7 with a mean NRS of 0.7 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0471) compared with participants treated with pulpotomy who had mean NRS of 2.4 and 1.2 respectively. Use of analgesics remained high between baseline and day 3 for participants treated with pulpotomy but significantly decreased for RCT (51.1%, 70\/137 vs. 33.3%, 46\/138;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0042). The use of analgesics was significantly reduced in both treatment groups between day 3 and day 7 but was significantly higher at day 7 for participants treated with pulpotomy compared to RCT (19.7%, 27\/137 vs. 9.4%, 13\/138;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0246). Early failure was significantly more common for participants who underwent pulpotomy treatment (10\/192; 5.2%) compared with RCT (1\/193; 0.5%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0141) and was associated with preoperative tenderness to percussion (TTP), molar teeth, sleep disturbance and prolonged bleeding time after exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The PROVE study provides the first robust evidence that both pulpotomy and RCT provided effective pain relief up to day 7; but significantly more pain relief and reduced analgesic intake were evident after RCT. Early failure rate was low in both groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70208","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:24:41Z","timestamp":1782732281000},"page":"2335-2345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short\u2010Term Outcomes of Full Pulpotomy Compared With Root Canal Treatment for Irreversible Pulpitis: The\n                    <scp>PROVE<\/scp>\n                    Study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7378","authenticated-orcid":false,"given":"I. A.","family":"El Karim","sequence":"first","affiliation":[{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-2379","authenticated-orcid":false,"given":"H. F.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Dublin Dental University Hospital, Trinity College Dublin  Dublin 2 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-751X","authenticated-orcid":false,"given":"S. G.","family":"Craig","sequence":"additional","affiliation":[{"name":"School of Medicine, Dentistry and Biomedical Sciences Queen's University Belfast  Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-9443","authenticated-orcid":false,"given":"V.","family":"Ballal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Narkedamalli","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Manipal College of Dental Sciences Manipal Academy of Higher Education  Manipal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-8850","authenticated-orcid":false,"given":"N. A.","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-0618","authenticated-orcid":false,"given":"R. H.","family":"Albanna","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Jordan University of Science and Technology  Irbid Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-6684","authenticated-orcid":false,"given":"P.","family":"Chompu\u2010inwai","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-4928","authenticated-orcid":false,"given":"T.","family":"Srisuwan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-9652","authenticated-orcid":false,"given":"V.","family":"Yu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0353-1793","authenticated-orcid":false,"given":"S.","family":"Chua","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-3198","authenticated-orcid":false,"given":"S.","family":"Saber","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The British University in Egypt (BUE)  Elsherouk Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9946-1082","authenticated-orcid":false,"given":"K. 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